| http://purl.uniprot.org/citations/21412788 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21412788 | http://www.w3.org/2000/01/rdf-schema#comment | "The localization of hepatitis C virus (HCV) proteins in cells leads to several problems. The translocase of outer mitochondrial membrane 70 (TOM70) is a mitochondrial import receptor. In this study, TOM70 expression was induced by HCV infection. TOM70 overexpression induced resistance to tumor necrosis factor-alpha (TNF-α)-mediated apoptosis but not to Fas-induced apoptosis in HepG2 cells. TOM70 was found to be induced by the HCV non-structural protein (NS)3/4A protein, and silencing of TOM70 decreased the levels of the NS3 and Mcl-1 proteins. These results indicate that TOM70 can directly interact with the NS3 protein. In hepatoma cells, silencing of TOM70 induced apoptosis and increased caspase-3/7 activity but did not modify caspase-8 and caspase-9 activity. TOM70 silencing-induced apoptosis was impaired in HCV NS3/4A protein-expressing cells. Thus, this study revealed a novel finding, that is, TOM70 is linked with the NS3 protein and the apoptotic response."xsd:string |
| http://purl.uniprot.org/citations/21412788 | http://purl.org/dc/terms/identifier | "doi:10.1002/jmv.22046"xsd:string |
| http://purl.uniprot.org/citations/21412788 | http://purl.uniprot.org/core/author | "Kai C."xsd:string |
| http://purl.uniprot.org/citations/21412788 | http://purl.uniprot.org/core/author | "Kohara M."xsd:string |
| http://purl.uniprot.org/citations/21412788 | http://purl.uniprot.org/core/author | "Nishimura T."xsd:string |
| http://purl.uniprot.org/citations/21412788 | http://purl.uniprot.org/core/author | "Saito M."xsd:string |
| http://purl.uniprot.org/citations/21412788 | http://purl.uniprot.org/core/author | "Takano T."xsd:string |
| http://purl.uniprot.org/citations/21412788 | http://purl.uniprot.org/core/author | "Tsukiyama-Kohara K."xsd:string |
| http://purl.uniprot.org/citations/21412788 | http://purl.uniprot.org/core/author | "Kasama Y."xsd:string |
| http://purl.uniprot.org/citations/21412788 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21412788 | http://purl.uniprot.org/core/name | "J Med Virol"xsd:string |
| http://purl.uniprot.org/citations/21412788 | http://purl.uniprot.org/core/pages | "801-809"xsd:string |
| http://purl.uniprot.org/citations/21412788 | http://purl.uniprot.org/core/title | "Translocase of outer mitochondrial membrane 70 expression is induced by hepatitis C virus and is related to the apoptotic response."xsd:string |
| http://purl.uniprot.org/citations/21412788 | http://purl.uniprot.org/core/volume | "83"xsd:string |
| http://purl.uniprot.org/citations/21412788 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21412788 |
| http://purl.uniprot.org/citations/21412788 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21412788 |
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