| http://purl.uniprot.org/citations/21414924 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21414924 | http://www.w3.org/2000/01/rdf-schema#comment | "Myelination is dependent on complex reciprocal interactions between the Schwann cell (SC) and axon. Recent evidence suggests that the SC-axon interface represents a membrane specialization essential for myelination; however, the manner in which this polarized-apical domain is generated remains a mystery. The cell adhesion molecule N-cadherin is enriched at the SC-axon interface and colocalizes with the polarity protein Par-3. The asymmetric localization is induced on SC-SC and SC-axon contact. Knockdown of N-cadherin in SCs cocultured with DRG neurons disrupts Par-3 localization and delays the initiation of myelination. However, knockdown or overexpression of neuronal N-cadherin does not influence the distribution of Par-3 or myelination, suggesting that homotypic interactions between SC and axonal N-cadherin are not essential for the events surrounding myelination. To further investigate the role of N-cadherin, mice displaying SC-specific gene ablation of N-cadherin were generated and characterized. Surprisingly, myelination is only slightly delayed, and mice are viable without any detectable myelination defects. β-Catenin, a downstream effector of N-cadherin, colocalizes and coimmunoprecipitates with N-cadherin on the initiation of myelination. To determine whether β-catenin mediates compensation on N-cadherin deletion, SC-specific gene ablation of β-catenin was generated and characterized. Consistent with our hypothesis, myelination is more severely delayed than when manipulating N-cadherin alone, but without any defect to the myelin sheath. Together, our results suggest that N-cadherin interacts with β-catenin in establishing SC polarity and the timely initiation of myelination, but they are nonessential components for the formation and maturation of the myelin sheath."xsd:string |
| http://purl.uniprot.org/citations/21414924 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.4345-10.2011"xsd:string |
| http://purl.uniprot.org/citations/21414924 | http://purl.uniprot.org/core/author | "Meijer D."xsd:string |
| http://purl.uniprot.org/citations/21414924 | http://purl.uniprot.org/core/author | "Chan J.R."xsd:string |
| http://purl.uniprot.org/citations/21414924 | http://purl.uniprot.org/core/author | "Shen Y.A."xsd:string |
| http://purl.uniprot.org/citations/21414924 | http://purl.uniprot.org/core/author | "Ng B.K."xsd:string |
| http://purl.uniprot.org/citations/21414924 | http://purl.uniprot.org/core/author | "De la Torre A.R."xsd:string |
| http://purl.uniprot.org/citations/21414924 | http://purl.uniprot.org/core/author | "Lewallen K.A."xsd:string |
| http://purl.uniprot.org/citations/21414924 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21414924 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/21414924 | http://purl.uniprot.org/core/pages | "3032-3043"xsd:string |
| http://purl.uniprot.org/citations/21414924 | http://purl.uniprot.org/core/title | "Assessing the role of the cadherin/catenin complex at the Schwann cell-axon interface and in the initiation of myelination."xsd:string |
| http://purl.uniprot.org/citations/21414924 | http://purl.uniprot.org/core/volume | "31"xsd:string |
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