| http://purl.uniprot.org/citations/21422625 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21422625 | http://www.w3.org/2000/01/rdf-schema#comment | "Type-1 diabetes mellitus (T1DM) is a progressive complex autoimmune disease in which combinations of environmental as well as genetic factors contribute to T-cell mediated destruction of insulin-secreting β-cells of the pancreas. HLA class II alleles on chromosome 6p21 [insulin dependent diabetes mellitus 1 (IDDM1)], especially DR and DQ, show strong association with T1DM. In addition, several studies have suggested that polymorphisms in the CTLA-4 gene (IDDM12) on chromosome 2q33 form part of the genetic susceptibility for type 1 diabetes. The aim of this study was to analyze HLA alleles of the DQB1 and DRB1 genes using polymerase chain reaction using sequence specific primers (PCR-SSP) technique and to investigate the association of the A49G CTLA-4 polymorphism using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis in Lebanese T1DM patients. The study was conducted on 39 Lebanese T1DM patients. Results of HLA typing showed an increased frequency of the HLA-DQB1FNx010201, HLA-DQB1FNx010302, HLA-DRB1FNx010301 and HLA-DRB1FNx010401 alleles, suggesting risk association and thus can be considered as susceptibility alleles. On the other hand, strong protection against the disease was conferred by the HLA-DRB1FNx01110101, HLA-DQB1FNx010301 and HLADQB1FNx010601 alleles. RFLP analysis of the A49G polymorphism showed a significant increase in the G allele and GG genotype frequencies in patients, suggesting that CTLA-4 may be considered as a susceptibility gene for the development of T1DM in the Lebanese population. Analysis of the two polymorphisms showed no detectable association between the two genes. However, a significant negative association of the G allele with the DQB1FNx010201 allele was observed. This might indicate that the two genetic risk factors, namely HLA and CTLA-4, act independently of each other with no additive effect."xsd:string |
| http://purl.uniprot.org/citations/21422625 | http://purl.uniprot.org/core/author | "Makki R.F."xsd:string |
| http://purl.uniprot.org/citations/21422625 | http://purl.uniprot.org/core/author | "Fakhoury H."xsd:string |
| http://purl.uniprot.org/citations/21422625 | http://purl.uniprot.org/core/author | "Chmaisse H.N."xsd:string |
| http://purl.uniprot.org/citations/21422625 | http://purl.uniprot.org/core/author | "Ei Wafai R.J."xsd:string |
| http://purl.uniprot.org/citations/21422625 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21422625 | http://purl.uniprot.org/core/name | "Saudi J Kidney Dis Transpl"xsd:string |
| http://purl.uniprot.org/citations/21422625 | http://purl.uniprot.org/core/pages | "273-281"xsd:string |
| http://purl.uniprot.org/citations/21422625 | http://purl.uniprot.org/core/title | "Association of HLA class II alleles and CTLA-4 polymorphism with type 1 diabetes."xsd:string |
| http://purl.uniprot.org/citations/21422625 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/21422625 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21422625 |
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