| http://purl.uniprot.org/citations/21422676 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21422676 | http://www.w3.org/2000/01/rdf-schema#comment | "ObjectiveTo investigate the relationship between patients diagnosed with nodal generalized osteoarthritis (NGOA) and tissue antigens HLA-A and HLA-B in the Western Black Sea Region of Turkey.Patients and methodsForty-six patients with NGOA (64.74±8.46) and 60 controls (62.32±6.8) were included in the study. Inclusion criteria were: (i) stage 2 and higher OA of the hand and knee based on the Kellgren-Lawrence classification, and (ii) stage 2 and higher lumbar disc degeneration according to Lawrence classification. Family histories were taken from patients. HLA-A and HLA-B were typed by PCR using sequence specific primer.ResultsThe frequencies of HLA-A(*)02 and HLA-B(*)38 were 58.7% and 15.2%, respectively, in patients with NGOA, and there was a statistically significant relationship between the disease and HLA-A(*)02 and HLA-B(*)38. The relationship between positive family history and HLA-B(*)44 allele was also statistically significant. In the control group, the frequency of HLA-A(*)29 was 11.7% and it was statistically significant.ConclusionTo our knowledge this is the first study to demonstrate the epidemiologic association between HLA-A(*)02 and HLA-B(*)38 with NGOA in our population. We conclude that, HLA-B(*)44 positivity may be associated with familial NGOA and HLA-A(*)29 may be a preventive factor against NGOA."xsd:string |
| http://purl.uniprot.org/citations/21422676 | http://purl.org/dc/terms/identifier | "doi:10.2169/internalmedicine.50.4646"xsd:string |
| http://purl.uniprot.org/citations/21422676 | http://purl.uniprot.org/core/author | "Sahin O."xsd:string |
| http://purl.uniprot.org/citations/21422676 | http://purl.uniprot.org/core/author | "Cogalgil S."xsd:string |
| http://purl.uniprot.org/citations/21422676 | http://purl.uniprot.org/core/author | "Tug E."xsd:string |
| http://purl.uniprot.org/citations/21422676 | http://purl.uniprot.org/core/author | "Dogruer D."xsd:string |
| http://purl.uniprot.org/citations/21422676 | http://purl.uniprot.org/core/author | "Tasligil C."xsd:string |
| http://purl.uniprot.org/citations/21422676 | http://purl.uniprot.org/core/author | "Tonuk B."xsd:string |
| http://purl.uniprot.org/citations/21422676 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21422676 | http://purl.uniprot.org/core/name | "Intern Med"xsd:string |
| http://purl.uniprot.org/citations/21422676 | http://purl.uniprot.org/core/pages | "545-550"xsd:string |
| http://purl.uniprot.org/citations/21422676 | http://purl.uniprot.org/core/title | "Relationship between primary nodal generalized osteoarthritis with tissue antigens HLA-A and HLA-B in the western Black Sea region of Turkey."xsd:string |
| http://purl.uniprot.org/citations/21422676 | http://purl.uniprot.org/core/volume | "50"xsd:string |
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