| http://purl.uniprot.org/citations/21423175 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21423175 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21423175 | http://www.w3.org/2000/01/rdf-schema#comment | "Activation of G-protein-coupled receptors (GPCRs) mobilizes compartmentalized pulses of cyclic AMP. The main cellular effector of cAMP is protein kinase A (PKA), which is assembled as an inactive holoenzyme consisting of two regulatory (R) and two catalytic (PKAc) subunits. cAMP binding to R subunits dissociates the holoenzyme and releases the catalytic moiety, which phosphorylates a wide array of cellular proteins. Reassociation of PKAc and R components terminates the signal. Here we report that the RING ligase praja2 controls the stability of mammalian R subunits. Praja2 forms a stable complex with, and is phosphorylated by, PKA. Rising cAMP levels promote praja2-mediated ubiquitylation and subsequent proteolysis of compartmentalized R subunits, leading to sustained substrate phosphorylation by the activated kinase. Praja2 is required for efficient nuclear cAMP signalling and for PKA-mediated long-term memory. Thus, praja2 regulates the total concentration of R subunits, tuning the strength and duration of PKA signal output in response to cAMP."xsd:string |
| http://purl.uniprot.org/citations/21423175 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb2209"xsd:string |
| http://purl.uniprot.org/citations/21423175 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb2209"xsd:string |
| http://purl.uniprot.org/citations/21423175 | http://purl.uniprot.org/core/author | "Stefan E."xsd:string |
| http://purl.uniprot.org/citations/21423175 | http://purl.uniprot.org/core/author | "Stefan E."xsd:string |
| http://purl.uniprot.org/citations/21423175 | http://purl.uniprot.org/core/author | "Annunziato L."xsd:string |
| http://purl.uniprot.org/citations/21423175 | http://purl.uniprot.org/core/author | "Annunziato L."xsd:string |
| http://purl.uniprot.org/citations/21423175 | http://purl.uniprot.org/core/author | "Carlucci A."xsd:string |
| http://purl.uniprot.org/citations/21423175 | http://purl.uniprot.org/core/author | "Carlucci A."xsd:string |
| http://purl.uniprot.org/citations/21423175 | http://purl.uniprot.org/core/author | "Feliciello A."xsd:string |
| http://purl.uniprot.org/citations/21423175 | http://purl.uniprot.org/core/author | "Feliciello A."xsd:string |
| http://purl.uniprot.org/citations/21423175 | http://purl.uniprot.org/core/author | "Lignitto L."xsd:string |
| http://purl.uniprot.org/citations/21423175 | http://purl.uniprot.org/core/author | "Lignitto L."xsd:string |
| http://purl.uniprot.org/citations/21423175 | http://purl.uniprot.org/core/author | "Savoia C."xsd:string |
| http://purl.uniprot.org/citations/21423175 | http://purl.uniprot.org/core/author | "Savoia C."xsd:string |
| http://purl.uniprot.org/citations/21423175 | http://purl.uniprot.org/core/author | "Scorziello A."xsd:string |
| http://purl.uniprot.org/citations/21423175 | http://purl.uniprot.org/core/author | "Scorziello A."xsd:string |
| http://purl.uniprot.org/citations/21423175 | http://purl.uniprot.org/core/author | "Garbi C."xsd:string |
| http://purl.uniprot.org/citations/21423175 | http://purl.uniprot.org/core/author | "Garbi C."xsd:string |
| http://purl.uniprot.org/citations/21423175 | http://purl.uniprot.org/core/author | "Cuomo O."xsd:string |
| http://purl.uniprot.org/citations/21423175 | http://purl.uniprot.org/core/author | "Cuomo O."xsd:string |
| http://purl.uniprot.org/citations/21423175 | http://purl.uniprot.org/core/author | "Nistico R."xsd:string |
| http://purl.uniprot.org/citations/21423175 | http://purl.uniprot.org/core/author | "Nistico R."xsd:string |