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http://purl.uniprot.org/citations/21425907http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
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Objectives

To assess serum interleukin (IL) 13 levels in atopic diseases and to determine the role of IL-13R A(1) gene polymorphism (+1398 A/G) in pathogenesis of these diseases.

Methods

Serum total immunoglobulin (Ig) E and IL-13 levels were measured by ELISA and the IL-13R A(1) gene (+1398 A/G) was screened by PCR-restriction fragment length polymorphism (RFLP) in 240 asthmatic children (120 atopic and 120 nonatopic) and 120 allergic rhinitis patients compared with 120 age-matched controls.

Results

No significant association was observed between genotype frequencies of the IL-13R A(1) +1398 A/G polymorphism in patients groups compared to in controls. There was a significant increase in serum levels of total IgE & IL-13 towards heterozygous AG and homozygous GG than homozygous AA in atopic asthma, non-atopic asthma and allergic rhinitis groups (P < 0.001 for each). A highly significant increase of serum IL-13 in atopic asthma as compared with controls (P < 0.001) and with nonatopic asthmatics (P < 0.001) was shown.

Conclusion

The IL-13R A(1) +1398 A/G polymorphism does not contribute to asthma or allergic rhinitis susceptibility, yet serum IL-13 can be used as a marker in atopic diseases and to differentiate between atopic and non-atopic asthma."xsd:string
http://purl.uniprot.org/citations/21425907http://purl.org/dc/terms/identifier"doi:10.3109/08820139.2011.565106"xsd:string
http://purl.uniprot.org/citations/21425907http://purl.uniprot.org/core/author"Mohamed R.H."xsd:string
http://purl.uniprot.org/citations/21425907http://purl.uniprot.org/core/author"Mohamed N.A."xsd:string
http://purl.uniprot.org/citations/21425907http://purl.uniprot.org/core/author"Hussein Y.M."xsd:string
http://purl.uniprot.org/citations/21425907http://purl.uniprot.org/core/author"Shalaby S.M."xsd:string
http://purl.uniprot.org/citations/21425907http://purl.uniprot.org/core/author"El-Sherbeny H.M."xsd:string
http://purl.uniprot.org/citations/21425907http://purl.uniprot.org/core/author"El-Tarhouny S.A."xsd:string
http://purl.uniprot.org/citations/21425907http://purl.uniprot.org/core/author"Hassan T.H."xsd:string
http://purl.uniprot.org/citations/21425907http://purl.uniprot.org/core/date"2011"xsd:gYear
http://purl.uniprot.org/citations/21425907http://purl.uniprot.org/core/name"Immunol Invest"xsd:string
http://purl.uniprot.org/citations/21425907http://purl.uniprot.org/core/pages"523-534"xsd:string
http://purl.uniprot.org/citations/21425907http://purl.uniprot.org/core/title"Interleukin-13 receptor A1 gene polymorphism and IL-13 serum level in atopic and non-atopic Egyptian children."xsd:string
http://purl.uniprot.org/citations/21425907http://purl.uniprot.org/core/volume"40"xsd:string
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