| http://purl.uniprot.org/citations/21428769 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21428769 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21428769 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundCarbamazepine causes various forms of hypersensitivity reactions, ranging from maculopapular exanthema to severe blistering reactions. The HLA-B*1502 allele has been shown to be strongly correlated with carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS-TEN) in the Han Chinese and other Asian populations but not in European populations.MethodsWe performed a genomewide association study of samples obtained from 22 subjects with carbamazepine-induced hypersensitivity syndrome, 43 subjects with carbamazepine-induced maculopapular exanthema, and 3987 control subjects, all of European descent. We tested for an association between disease and HLA alleles through proxy single-nucleotide polymorphisms and imputation, confirming associations by high-resolution sequence-based HLA typing. We replicated the associations in samples from 145 subjects with carbamazepine-induced hypersensitivity reactions.ResultsThe HLA-A*3101 allele, which has a prevalence of 2 to 5% in Northern European populations, was significantly associated with the hypersensitivity syndrome (P=3.5×10(-8)). An independent genomewide association study of samples from subjects with maculopapular exanthema also showed an association with the HLA-A*3101 allele (P=1.1×10(-6)). Follow-up genotyping confirmed the variant as a risk factor for the hypersensitivity syndrome (odds ratio, 12.41; 95% confidence interval [CI], 1.27 to 121.03), maculopapular exanthema (odds ratio, 8.33; 95% CI, 3.59 to 19.36), and SJS-TEN (odds ratio, 25.93; 95% CI, 4.93 to 116.18).ConclusionsThe presence of the HLA-A*3101 allele was associated with carbamazepine-induced hypersensitivity reactions among subjects of Northern European ancestry. The presence of the allele increased the risk from 5.0% to 26.0%, whereas its absence reduced the risk from 5.0% to 3.8%. (Funded by the U.K. Department of Health and others.)."xsd:string |
| http://purl.uniprot.org/citations/21428769 | http://purl.org/dc/terms/identifier | "doi:10.1056/nejmoa1013297"xsd:string |
| http://purl.uniprot.org/citations/21428769 | http://purl.org/dc/terms/identifier | "doi:10.1056/nejmoa1013297"xsd:string |
| http://purl.uniprot.org/citations/21428769 | http://purl.uniprot.org/core/author | "Deloukas P."xsd:string |
| http://purl.uniprot.org/citations/21428769 | http://purl.uniprot.org/core/author | "Deloukas P."xsd:string |
| http://purl.uniprot.org/citations/21428769 | http://purl.uniprot.org/core/author | "Carrington M."xsd:string |
| http://purl.uniprot.org/citations/21428769 | http://purl.uniprot.org/core/author | "Carrington M."xsd:string |
| http://purl.uniprot.org/citations/21428769 | http://purl.uniprot.org/core/author | "Jia X."xsd:string |
| http://purl.uniprot.org/citations/21428769 | http://purl.uniprot.org/core/author | "Jia X."xsd:string |
| http://purl.uniprot.org/citations/21428769 | http://purl.uniprot.org/core/author | "Depondt C."xsd:string |
| http://purl.uniprot.org/citations/21428769 | http://purl.uniprot.org/core/author | "Depondt C."xsd:string |
| http://purl.uniprot.org/citations/21428769 | http://purl.uniprot.org/core/author | "Goldstein D.B."xsd:string |
| http://purl.uniprot.org/citations/21428769 | http://purl.uniprot.org/core/author | "Goldstein D.B."xsd:string |
| http://purl.uniprot.org/citations/21428769 | http://purl.uniprot.org/core/author | "Heinzen E.L."xsd:string |
| http://purl.uniprot.org/citations/21428769 | http://purl.uniprot.org/core/author | "Heinzen E.L."xsd:string |
| http://purl.uniprot.org/citations/21428769 | http://purl.uniprot.org/core/author | "Pandolfo M."xsd:string |
| http://purl.uniprot.org/citations/21428769 | http://purl.uniprot.org/core/author | "Pandolfo M."xsd:string |
| http://purl.uniprot.org/citations/21428769 | http://purl.uniprot.org/core/author | "Bourgeois S."xsd:string |
| http://purl.uniprot.org/citations/21428769 | http://purl.uniprot.org/core/author | "Bourgeois S."xsd:string |
| http://purl.uniprot.org/citations/21428769 | http://purl.uniprot.org/core/author | "Delanty N."xsd:string |
| http://purl.uniprot.org/citations/21428769 | http://purl.uniprot.org/core/author | "Delanty N."xsd:string |
| http://purl.uniprot.org/citations/21428769 | http://purl.uniprot.org/core/author | "Johnson M.R."xsd:string |
| http://purl.uniprot.org/citations/21428769 | http://purl.uniprot.org/core/author | "Johnson M.R."xsd:string |