| http://purl.uniprot.org/citations/21430051 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21430051 | http://www.w3.org/2000/01/rdf-schema#comment | "Us3, a serine/threonine kinase encoded by all alphaherpesviruses, plays diverse roles during virus infection, including preventing virus-induced apoptosis, facilitating nuclear egress of capsids, stimulating mRNA translation and promoting cell-to-cell spread of virus infection. Given this diversity, the full spectrum of Us3 function may not yet be recognized. We noted, in transiently transfected cells, that herpes simplex virus type 2 (HSV-2) Us3 disrupted promyelocytic leukemia protein nuclear bodies (PML-NBs). However, PML-NB disruption was not observed in cells expressing catalytically inactive HSV-2 Us3. Analysis of PML-NBs in Vero cells transfected with pseudorabies virus (PRV) Us3 and those in Vero cells infected with Us3-null or -repaired PRV strains indicated that PRV Us3 expression also leads to the disruption of PML-NBs. While loss of PML-NBs in response to Us3 expression was prevented by the proteasome inhibitor MG132, Us3-mediated degradation of PML was not observed in infected cells or in transfected cells expressing enhanced green fluorescent protein (EGFP)-tagged PML isoform IV. These findings demonstrate that Us3 orthologues derived from distantly related alphaherpesviruses cause a disruption of PML-NBs in a kinase- and proteasome-dependent manner but, unlike the alphaherpesvirus ICP0 orthologues, do not target PML for degradation."xsd:string |
| http://purl.uniprot.org/citations/21430051 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.00022-11"xsd:string |
| http://purl.uniprot.org/citations/21430051 | http://purl.uniprot.org/core/author | "Jung M."xsd:string |
| http://purl.uniprot.org/citations/21430051 | http://purl.uniprot.org/core/author | "Banfield B.W."xsd:string |
| http://purl.uniprot.org/citations/21430051 | http://purl.uniprot.org/core/author | "Finnen R.L."xsd:string |
| http://purl.uniprot.org/citations/21430051 | http://purl.uniprot.org/core/author | "Neron C.E."xsd:string |
| http://purl.uniprot.org/citations/21430051 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21430051 | http://purl.uniprot.org/core/name | "J Virol"xsd:string |
| http://purl.uniprot.org/citations/21430051 | http://purl.uniprot.org/core/pages | "5301-5311"xsd:string |
| http://purl.uniprot.org/citations/21430051 | http://purl.uniprot.org/core/title | "The alphaherpesvirus serine/threonine kinase us3 disrupts promyelocytic leukemia protein nuclear bodies."xsd:string |
| http://purl.uniprot.org/citations/21430051 | http://purl.uniprot.org/core/volume | "85"xsd:string |
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