| http://purl.uniprot.org/citations/21430066 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21430066 | http://www.w3.org/2000/01/rdf-schema#comment | "Strategies to activate and rescue exhausted tumor-specific T cells, including the use of monoclonal antibodies (mAb) that block the negative costimulatory receptors CTLA-4 and PD-1 are proving very effective, but TIM3 has been relatively neglected as a target. Here we report an extensive characterization of the therapeutic activity and mechanism of action of an anti-mouse TIM3 mAb against experimental and carcinogen-induced tumors. For the first time we specifically define the mechanism of antitumor action of anti-TIM3 requiring IFN-γ producing CD8(+) T cells and CD4(+) T cells, and a higher ratio of tumor infiltrating CD8(+):CD4(+) T cells correlating with therapeutic success. Interestingly, in some models, anti-TIM3 appeared to be effective sometime before the appearance and accumulation of significant TIM3(+)PD-1(+) T cell populations in tumor bearing mice. Anti-TIM3 displayed modest prophylactic and therapeutic activity against a small fraction of carcinogen-induced sarcomas, but comparative and combination studies of anti-TIM3 with anti-CTLA-4 and anti-PD-1 against experimental and carcinogen-induced tumors suggested that these agents might be well-tolerated and very effective in combination."xsd:string |
| http://purl.uniprot.org/citations/21430066 | http://purl.org/dc/terms/identifier | "doi:10.1158/0008-5472.can-11-0096"xsd:string |
| http://purl.uniprot.org/citations/21430066 | http://purl.uniprot.org/core/author | "Yagita H."xsd:string |
| http://purl.uniprot.org/citations/21430066 | http://purl.uniprot.org/core/author | "Akiba H."xsd:string |
| http://purl.uniprot.org/citations/21430066 | http://purl.uniprot.org/core/author | "Smyth M.J."xsd:string |
| http://purl.uniprot.org/citations/21430066 | http://purl.uniprot.org/core/author | "Ngiow S.F."xsd:string |
| http://purl.uniprot.org/citations/21430066 | http://purl.uniprot.org/core/author | "Teng M.W."xsd:string |
| http://purl.uniprot.org/citations/21430066 | http://purl.uniprot.org/core/author | "von Scheidt B."xsd:string |
| http://purl.uniprot.org/citations/21430066 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21430066 | http://purl.uniprot.org/core/name | "Cancer Res"xsd:string |
| http://purl.uniprot.org/citations/21430066 | http://purl.uniprot.org/core/pages | "3540-3551"xsd:string |
| http://purl.uniprot.org/citations/21430066 | http://purl.uniprot.org/core/title | "Anti-TIM3 antibody promotes T cell IFN-gamma-mediated antitumor immunity and suppresses established tumors."xsd:string |
| http://purl.uniprot.org/citations/21430066 | http://purl.uniprot.org/core/volume | "71"xsd:string |
| http://purl.uniprot.org/citations/21430066 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21430066 |
| http://purl.uniprot.org/citations/21430066 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21430066 |
| http://purl.uniprot.org/uniprot/#_P70443-mappedCitation-21430066 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21430066 |
| http://purl.uniprot.org/uniprot/#_A0A7R8C347-mappedCitation-21430066 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21430066 |
| http://purl.uniprot.org/uniprot/#_A0A7R8GUN6-mappedCitation-21430066 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21430066 |
| http://purl.uniprot.org/uniprot/#_B8ZZZ4-mappedCitation-21430066 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21430066 |
| http://purl.uniprot.org/uniprot/#_A8YQE4-mappedCitation-21430066 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21430066 |
| http://purl.uniprot.org/uniprot/#_B3KUU3-mappedCitation-21430066 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21430066 |
| http://purl.uniprot.org/uniprot/#_A1Z2M2-mappedCitation-21430066 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21430066 |
| http://purl.uniprot.org/uniprot/#_A3RL32-mappedCitation-21430066 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21430066 |
| http://purl.uniprot.org/uniprot/#_C4NUL9-mappedCitation-21430066 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21430066 |