| http://purl.uniprot.org/citations/21435446 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21435446 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21435446 | http://www.w3.org/2000/01/rdf-schema#comment | "Calcineurin is an important signal transduction mediator in T cells, neurons, the heart, and kidneys. Recent evidence points to unique actions of the two main isoforms of the catalytic subunit. Although the β isoform is required for T-cell development, α is important in the brain and kidney. In addition, mice lacking α but not β suffer from failure to thrive and early mortality. The purpose of this study was to identify the cause of postnatal death of calcineurin α null (CnAα(-/-)) mice and to determine the mechanism of α activity that contributes to the phenotype. CnAα(-/-) mice and wild-type littermate controls were fed a modified diet and then salivary gland function and histology were examined. In vitro studies were performed to identify the mechanism of α action. Data show that calcineurin is required for normal submandibular gland function and secretion of digestive enzymes. Loss of α does not impair nuclear factor of activated T-cell activity or expression but results in impaired protein trafficking downstream of the inositol trisphosphate receptor. These findings show a novel function of calcineurin in digestion and protein trafficking. Significantly, these data also provide a mechanism to rescue to adulthood a valuable animal model of calcineurin inhibitor-mediated neuronal and renal toxicities."xsd:string |
| http://purl.uniprot.org/citations/21435446 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ajpath.2010.12.054"xsd:string |
| http://purl.uniprot.org/citations/21435446 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ajpath.2010.12.054"xsd:string |
| http://purl.uniprot.org/citations/21435446 | http://purl.uniprot.org/core/author | "Williams S.R."xsd:string |
| http://purl.uniprot.org/citations/21435446 | http://purl.uniprot.org/core/author | "Williams S.R."xsd:string |
| http://purl.uniprot.org/citations/21435446 | http://purl.uniprot.org/core/author | "Gooch J.L."xsd:string |
| http://purl.uniprot.org/citations/21435446 | http://purl.uniprot.org/core/author | "Gooch J.L."xsd:string |
| http://purl.uniprot.org/citations/21435446 | http://purl.uniprot.org/core/author | "Price S.R."xsd:string |
| http://purl.uniprot.org/citations/21435446 | http://purl.uniprot.org/core/author | "Price S.R."xsd:string |
| http://purl.uniprot.org/citations/21435446 | http://purl.uniprot.org/core/author | "Pena J.A."xsd:string |
| http://purl.uniprot.org/citations/21435446 | http://purl.uniprot.org/core/author | "Pena J.A."xsd:string |
| http://purl.uniprot.org/citations/21435446 | http://purl.uniprot.org/core/author | "Reddy R.N."xsd:string |
| http://purl.uniprot.org/citations/21435446 | http://purl.uniprot.org/core/author | "Reddy R.N."xsd:string |
| http://purl.uniprot.org/citations/21435446 | http://purl.uniprot.org/core/author | "Roberts B.R."xsd:string |
| http://purl.uniprot.org/citations/21435446 | http://purl.uniprot.org/core/author | "Roberts B.R."xsd:string |
| http://purl.uniprot.org/citations/21435446 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21435446 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21435446 | http://purl.uniprot.org/core/name | "Am. J. Pathol."xsd:string |
| http://purl.uniprot.org/citations/21435446 | http://purl.uniprot.org/core/name | "Am. J. Pathol."xsd:string |
| http://purl.uniprot.org/citations/21435446 | http://purl.uniprot.org/core/pages | "1605-1613"xsd:string |
| http://purl.uniprot.org/citations/21435446 | http://purl.uniprot.org/core/pages | "1605-1613"xsd:string |
| http://purl.uniprot.org/citations/21435446 | http://purl.uniprot.org/core/title | "Rescue of calcineurin Aalpha(-/-) mice reveals a novel role for the alpha isoform in the salivary gland."xsd:string |
| http://purl.uniprot.org/citations/21435446 | http://purl.uniprot.org/core/title | "Rescue of calcineurin Aalpha(-/-) mice reveals a novel role for the alpha isoform in the salivary gland."xsd:string |