| http://purl.uniprot.org/citations/21436383 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21436383 | http://www.w3.org/2000/01/rdf-schema#comment | "Nonsteroidal anti-inflammatory drugs (NSAID) appear to be effective cancer chemopreventives. Previous cellular studies showed that aspirin (acetylsalicylic acid: ASA) and nitric oxide-donating ASA (NO-ASA) suppressed microsatellite instability (MSI) in mismatch repair (MMR)-deficient cells linked to the common cancer predisposition syndrome hereditary nonpolyposis colorectal cancer or Lynch syndrome (LS/HNPCC), at doses 300-to 3,000-fold less than ASA. Using a mouse model that develops MMR-deficient intestinal tumors that appear pathologically identical to LS/HNPCC, we show that ASA (400 mg/kg) and low-dose NO-ASA (72 mg/kg) increased life span by 18% to 21%. We also note a trend where ASA treatment resulted in intestinal tumors with reduced high MSI (H-MSI) and increased low MSI (L-MSI) as defined by the Bethesda Criteria. Low-dose NO-ASA had a minimal effect on MSI status. In contrast to previous studies, high-dose NO-ASA (720/1,500 mg/kg) treatments increased tumor burden, decreased life span, and exacerbated MSI uniquely in the LS/HNPCC mouse model. These results suggest that MMR-deficient tissues/mice may be specifically sensitive to intrinsic pharmacokinetic features of this drug. It is likely that long-term treatment with ASA may represent a chemopreventive option for LS/HNPCC patients. Moreover, as low-dose NO-ASA shows equivalent life span increase at 10-fold lower doses than ASA, it may have the potential to significantly reduce the gastropathy associated with long-term ASA treatment."xsd:string |
| http://purl.uniprot.org/citations/21436383 | http://purl.org/dc/terms/identifier | "doi:10.1158/1940-6207.capr-10-0319"xsd:string |
| http://purl.uniprot.org/citations/21436383 | http://purl.uniprot.org/core/author | "Kucherlapati R."xsd:string |
| http://purl.uniprot.org/citations/21436383 | http://purl.uniprot.org/core/author | "Fishel R."xsd:string |
| http://purl.uniprot.org/citations/21436383 | http://purl.uniprot.org/core/author | "Edelmann W."xsd:string |
| http://purl.uniprot.org/citations/21436383 | http://purl.uniprot.org/core/author | "McIlhatton M.A."xsd:string |
| http://purl.uniprot.org/citations/21436383 | http://purl.uniprot.org/core/author | "Kopelovich L."xsd:string |
| http://purl.uniprot.org/citations/21436383 | http://purl.uniprot.org/core/author | "Tyler J."xsd:string |
| http://purl.uniprot.org/citations/21436383 | http://purl.uniprot.org/core/author | "Kerepesi L.A."xsd:string |
| http://purl.uniprot.org/citations/21436383 | http://purl.uniprot.org/core/author | "Kucherlapati M.H."xsd:string |
| http://purl.uniprot.org/citations/21436383 | http://purl.uniprot.org/core/author | "Bocker-Edmonston T."xsd:string |
| http://purl.uniprot.org/citations/21436383 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21436383 | http://purl.uniprot.org/core/name | "Cancer Prev Res (Phila)"xsd:string |
| http://purl.uniprot.org/citations/21436383 | http://purl.uniprot.org/core/pages | "684-693"xsd:string |
| http://purl.uniprot.org/citations/21436383 | http://purl.uniprot.org/core/title | "Aspirin and low-dose nitric oxide-donating aspirin increase life span in a Lynch syndrome mouse model."xsd:string |
| http://purl.uniprot.org/citations/21436383 | http://purl.uniprot.org/core/volume | "4"xsd:string |
| http://purl.uniprot.org/citations/21436383 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21436383 |
| http://purl.uniprot.org/citations/21436383 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21436383 |
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| http://purl.uniprot.org/uniprot/#_G3UXD8-mappedCitation-21436383 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21436383 |
| http://purl.uniprot.org/uniprot/#_Q3TZI5-mappedCitation-21436383 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21436383 |
| http://purl.uniprot.org/uniprot/#_P43247-mappedCitation-21436383 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21436383 |
| http://purl.uniprot.org/uniprot/#_Q80V79-mappedCitation-21436383 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21436383 |
| http://purl.uniprot.org/uniprot/P43247 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21436383 |