| http://purl.uniprot.org/citations/21437278 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21437278 | http://www.w3.org/2000/01/rdf-schema#comment | "Telomere Position Effect (TPE) is governed by strong repression signals emitted by telomeres via the Sir2/3/4 Histone Deacetylase complex. These signals are then relayed by weak proto-silencers residing in the subtelomeric core X and Y' elements. Subtelomeres also contain Sub-Telomeric Anti-silencing Regions (STARs). In this study we have prepared telomeres built of different combinations of core X, Y' and STARs and have analyzed them in strains lacking Histone-Acetyltransferase genes as well as in cdc6-1 and Δrif1 strains. We show that core X and Y' dramatically reduce both positive and negative variations in TPE, that are caused by these mutations. We also show that the deletion of Histone-Acetyltransferase genes reduce the silencing activity of an ACS proto-silencer, but also reduce the anti-silencing activity of a STAR. We postulate that core X and Y' act as epigenetic "cushioning" cis-elements."xsd:string |
| http://purl.uniprot.org/citations/21437278 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0017523"xsd:string |
| http://purl.uniprot.org/citations/21437278 | http://purl.uniprot.org/core/author | "Chatterji A."xsd:string |
| http://purl.uniprot.org/citations/21437278 | http://purl.uniprot.org/core/author | "Power P."xsd:string |
| http://purl.uniprot.org/citations/21437278 | http://purl.uniprot.org/core/author | "Jeffery D."xsd:string |
| http://purl.uniprot.org/citations/21437278 | http://purl.uniprot.org/core/author | "Yankulov K."xsd:string |
| http://purl.uniprot.org/citations/21437278 | http://purl.uniprot.org/core/author | "Rehman M.A."xsd:string |
| http://purl.uniprot.org/citations/21437278 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21437278 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/21437278 | http://purl.uniprot.org/core/pages | "e17523"xsd:string |
| http://purl.uniprot.org/citations/21437278 | http://purl.uniprot.org/core/title | "Sub-telomeric core X and Y' elements in S. cerevisiae suppress extreme variations in gene silencing."xsd:string |
| http://purl.uniprot.org/citations/21437278 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/21437278 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21437278 |
| http://purl.uniprot.org/citations/21437278 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21437278 |
| http://purl.uniprot.org/uniprot/#_Q07794-mappedCitation-21437278 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21437278 |
| http://purl.uniprot.org/uniprot/#_Q08032-mappedCitation-21437278 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21437278 |
| http://purl.uniprot.org/uniprot/#_P34218-mappedCitation-21437278 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21437278 |
| http://purl.uniprot.org/uniprot/#_P06243-mappedCitation-21437278 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21437278 |
| http://purl.uniprot.org/uniprot/#_P29496-mappedCitation-21437278 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21437278 |
| http://purl.uniprot.org/uniprot/#_P29539-mappedCitation-21437278 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21437278 |
| http://purl.uniprot.org/uniprot/#_P40963-mappedCitation-21437278 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21437278 |
| http://purl.uniprot.org/uniprot/#_Q03330-mappedCitation-21437278 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21437278 |
| http://purl.uniprot.org/uniprot/#_P09119-mappedCitation-21437278 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21437278 |
| http://purl.uniprot.org/uniprot/#_P50874-mappedCitation-21437278 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21437278 |