| http://purl.uniprot.org/citations/21437966 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21437966 | http://www.w3.org/2000/01/rdf-schema#comment | "Catabolic inflammatory cytokines are prevalent in osteoarthritis (OA). The purpose of this study was to evaluate an autologous protein solution (APS) as a potential chondroprotective agent for OA therapy. APS was prepared from platelet-rich plasma (PRP). The APS solution contained both anabolic (bFGF, TGF-β1, TGF-β2, EGF, IGF-1, PDGF-AB, PDGF-BB, and VEGF) and anti-inflammatory (IL-1ra, sTNF-RI, sTNF-RII, IL-4, IL-10, IL-13, and IFNγ) cytokines but low concentrations of catabolic cytokines (IL-1α, IL-1β, TNFα, IL-6, IL-8, IL-17, and IL-18). Human articular chondrocytes were pre-incubated with the antagonists IL-1ra, sTNF-RI, or APS prior to the addition of recombinant human IL-1β or TNFα. Following exposure to inflammatory cytokines, the levels of MMP-13 in the culture medium were evaluated by ELISA. MMP-13 production stimulated in chondrocytes by IL-1β or TNFα was reduced by rhIL-1ra and sTNF-RI to near basal levels. APS was also capable of inhibiting the production of MMP-13 induced by both IL-1β and TNFα. The combination of anabolic and anti-inflammatory cytokines in the APS created from PRP may render this formulation to be a potential candidate for the treatment of inflammation in patients at early stages of OA."xsd:string |
| http://purl.uniprot.org/citations/21437966 | http://purl.org/dc/terms/identifier | "doi:10.1002/jor.21384"xsd:string |
| http://purl.uniprot.org/citations/21437966 | http://purl.uniprot.org/core/author | "Hoeppner J."xsd:string |
| http://purl.uniprot.org/citations/21437966 | http://purl.uniprot.org/core/author | "Matuska A."xsd:string |
| http://purl.uniprot.org/citations/21437966 | http://purl.uniprot.org/core/author | "O'Shaughnessey K."xsd:string |
| http://purl.uniprot.org/citations/21437966 | http://purl.uniprot.org/core/author | "Oyster M."xsd:string |
| http://purl.uniprot.org/citations/21437966 | http://purl.uniprot.org/core/author | "Welch Z."xsd:string |
| http://purl.uniprot.org/citations/21437966 | http://purl.uniprot.org/core/author | "Woodell-May J."xsd:string |
| http://purl.uniprot.org/citations/21437966 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21437966 | http://purl.uniprot.org/core/name | "J Orthop Res"xsd:string |
| http://purl.uniprot.org/citations/21437966 | http://purl.uniprot.org/core/pages | "1320-1326"xsd:string |
| http://purl.uniprot.org/citations/21437966 | http://purl.uniprot.org/core/title | "Autologous protein solution inhibits MMP-13 production by IL-1beta and TNFalpha-stimulated human articular chondrocytes."xsd:string |
| http://purl.uniprot.org/citations/21437966 | http://purl.uniprot.org/core/volume | "29"xsd:string |
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