| http://purl.uniprot.org/citations/21438871 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21438871 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin (IL)-17 plays an important role in the pathogenesis in a number of immune inflammatory disorders. This study aims to investigate the mechanism by which microbial product flagellin is involved in the development of T helper type (Th)17 cells. Serum levels of IL-17 and CXCL9-11 in patients with ulcerative colitis (UC) were evaluated. The source and mechanism of CXC11 release in intestinal mucosa were examined with colonic biopsies from UC patients and a colitis mouse model. The role of flagellin in the development of Th17 cells was studied with a cell co-culture system. High serum levels of CXCL11 and IL-17 were observed in UC. Flagellin could induce the production of CXCL11 in CD14(+) cells that facilitated the development of Th17 cells. In a skewed Th1 response environment flagellin induces intestinal inflammation, with IL-17 expression predominant. CXCR3/CXCL11 pathway is involved in microbial product flagellin-induced intestinal inflammation in which the Th17 response plays an important role."xsd:string |
| http://purl.uniprot.org/citations/21438871 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1365-2249.2011.04382.x"xsd:string |
| http://purl.uniprot.org/citations/21438871 | http://purl.uniprot.org/core/author | "Chen X."xsd:string |
| http://purl.uniprot.org/citations/21438871 | http://purl.uniprot.org/core/author | "Du Y."xsd:string |
| http://purl.uniprot.org/citations/21438871 | http://purl.uniprot.org/core/author | "Liu Z."xsd:string |
| http://purl.uniprot.org/citations/21438871 | http://purl.uniprot.org/core/author | "Su J."xsd:string |
| http://purl.uniprot.org/citations/21438871 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
| http://purl.uniprot.org/citations/21438871 | http://purl.uniprot.org/core/author | "Song C.H."xsd:string |
| http://purl.uniprot.org/citations/21438871 | http://purl.uniprot.org/core/author | "Yang P.C."xsd:string |
| http://purl.uniprot.org/citations/21438871 | http://purl.uniprot.org/core/author | "Chen X.'"xsd:string |
| http://purl.uniprot.org/citations/21438871 | http://purl.uniprot.org/core/author | "Yaseen S.A."xsd:string |
| http://purl.uniprot.org/citations/21438871 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21438871 | http://purl.uniprot.org/core/name | "Clin Exp Immunol"xsd:string |
| http://purl.uniprot.org/citations/21438871 | http://purl.uniprot.org/core/pages | "396-406"xsd:string |
| http://purl.uniprot.org/citations/21438871 | http://purl.uniprot.org/core/title | "Chemokine CXCL11 links microbial stimuli to intestinal inflammation."xsd:string |
| http://purl.uniprot.org/citations/21438871 | http://purl.uniprot.org/core/volume | "164"xsd:string |
| http://purl.uniprot.org/citations/21438871 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21438871 |
| http://purl.uniprot.org/citations/21438871 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21438871 |
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| http://purl.uniprot.org/uniprot/#_P12850-mappedCitation-21438871 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21438871 |
| http://purl.uniprot.org/uniprot/#_Q5U5W9-mappedCitation-21438871 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21438871 |
| http://purl.uniprot.org/uniprot/#_Q96KF0-mappedCitation-21438871 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21438871 |
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