| http://purl.uniprot.org/citations/21452305 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21452305 | http://www.w3.org/2000/01/rdf-schema#comment | "The differentiation of bone marrow mesenchymal stem cells (MSCs) into osteoblasts is a crucial step during bone formation. However, the mechanisms regulating the early stages of osteogenic differentiation are not fully understood. In the present study, we found that growth-arrest specific gene 7b (Gas7b) was up-regulated during dexamethasone-induced differentiation of human MSCs (hMSCs) into osteoblasts. Knockdown of Gas7 using short-hairpin RNA decreased the expression of the osteogenic transcription factor Runx2 and its target genes alkaline phosphatase, type I collagen, osteocalcin (OC), and osteopontin. In addition, knockdown of Gas7 decreased matrix mineralization of dexamethasone-treated hMSCs in vitro. In contrast, ectopic expression of Gas7 isoforms a and b promoted gene expression associated with osteoblast differentiation and matrix mineralization, and also induced the mineralization of hMSCs in vitro. Furthermore, a gene reporter assay designed to monitor OC expression in hMSCs revealed that Runx2-dependent transcriptional activity was enhanced by over-expression of human Gas7 isoforms a and b. These findings reveal that Gas7 regulates the differentiation of hMSCs into osteoblasts by enhancing Runx2-dependent gene expression."xsd:string |
| http://purl.uniprot.org/citations/21452305 | http://purl.org/dc/terms/identifier | "doi:10.1002/jor.21425"xsd:string |
| http://purl.uniprot.org/citations/21452305 | http://purl.uniprot.org/core/author | "Chang Y."xsd:string |
| http://purl.uniprot.org/citations/21452305 | http://purl.uniprot.org/core/author | "Lin-Chao S."xsd:string |
| http://purl.uniprot.org/citations/21452305 | http://purl.uniprot.org/core/author | "Chao C.C."xsd:string |
| http://purl.uniprot.org/citations/21452305 | http://purl.uniprot.org/core/author | "Hung F.C."xsd:string |
| http://purl.uniprot.org/citations/21452305 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21452305 | http://purl.uniprot.org/core/name | "J Orthop Res"xsd:string |
| http://purl.uniprot.org/citations/21452305 | http://purl.uniprot.org/core/pages | "1528-1535"xsd:string |
| http://purl.uniprot.org/citations/21452305 | http://purl.uniprot.org/core/title | "Gas7 mediates the differentiation of human bone marrow-derived mesenchymal stem cells into functional osteoblasts by enhancing Runx2-dependent gene expression."xsd:string |
| http://purl.uniprot.org/citations/21452305 | http://purl.uniprot.org/core/volume | "29"xsd:string |
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