| http://purl.uniprot.org/citations/21453014 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21453014 | http://www.w3.org/2000/01/rdf-schema#comment | "Glucocorticoids are widely used immunosuppressive drugs in treatment of autoimmune diseases and hematological malignancies. Glucocorticoids are particularly effective immune suppressants, because they induce rapid peripheral T cell and thymocyte apoptosis resulting in impaired T cell-dependent immune responses. Although glucocorticoids can induce apoptotic cell death directly in developing thymocytes, how exogenous glucocorticoids affect the thymic epithelial network that provides the microenvironment for T cell development is still largely unknown. In the present work, we show that primary thymic epithelial cells (TECs) express glucocorticoid receptors and that high-dosage dexamethasone induces degeneration of the thymic epithelium within 24 h of treatment. Changes in organ morphology are accompanied by a decrease in the TEC transcription factor FoxN1 and its regulator Wnt-4 parallel with upregulation of lamina-associated polypeptide 2α and peroxisome proliferator activator receptor γ, two characteristic molecular markers for adipose thymic involution. Overexpression of Wnt-4, however, can prevent upregulation of adipose differentiation-related aging markers, suggesting an important role of Wnt-4 in thymic senescence."xsd:string |
| http://purl.uniprot.org/citations/21453014 | http://purl.org/dc/terms/identifier | "doi:10.1089/rej.2010.1110"xsd:string |
| http://purl.uniprot.org/citations/21453014 | http://purl.uniprot.org/core/author | "Anderson G."xsd:string |
| http://purl.uniprot.org/citations/21453014 | http://purl.uniprot.org/core/author | "Berki T."xsd:string |
| http://purl.uniprot.org/citations/21453014 | http://purl.uniprot.org/core/author | "Varecza Z."xsd:string |
| http://purl.uniprot.org/citations/21453014 | http://purl.uniprot.org/core/author | "Jenkinson E.J."xsd:string |
| http://purl.uniprot.org/citations/21453014 | http://purl.uniprot.org/core/author | "Boldizsar F."xsd:string |
| http://purl.uniprot.org/citations/21453014 | http://purl.uniprot.org/core/author | "Parnell S.M."xsd:string |
| http://purl.uniprot.org/citations/21453014 | http://purl.uniprot.org/core/author | "Kvell K."xsd:string |
| http://purl.uniprot.org/citations/21453014 | http://purl.uniprot.org/core/author | "Pongracz J.E."xsd:string |
| http://purl.uniprot.org/citations/21453014 | http://purl.uniprot.org/core/author | "Talaber G."xsd:string |
| http://purl.uniprot.org/citations/21453014 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21453014 | http://purl.uniprot.org/core/name | "Rejuvenation Res"xsd:string |
| http://purl.uniprot.org/citations/21453014 | http://purl.uniprot.org/core/pages | "241-248"xsd:string |
| http://purl.uniprot.org/citations/21453014 | http://purl.uniprot.org/core/title | "Wnt-4 protects thymic epithelial cells against dexamethasone-induced senescence."xsd:string |
| http://purl.uniprot.org/citations/21453014 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/21453014 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21453014 |
| http://purl.uniprot.org/citations/21453014 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21453014 |
| http://purl.uniprot.org/uniprot/#_P22724-mappedCitation-21453014 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21453014 |
| http://purl.uniprot.org/uniprot/#_Q3ZB23-mappedCitation-21453014 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21453014 |
| http://purl.uniprot.org/uniprot/#_Q91ZN8-mappedCitation-21453014 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21453014 |
| http://purl.uniprot.org/uniprot/Q91ZN8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21453014 |
| http://purl.uniprot.org/uniprot/P22724 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21453014 |
| http://purl.uniprot.org/uniprot/Q3ZB23 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21453014 |