| http://purl.uniprot.org/citations/21454316 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21454316 | http://www.w3.org/2000/01/rdf-schema#comment | "Urocortin 2 (Ucn 2) and urocortin 3 (Ucn 3) are neuropeptides expressed by human endometrium. This study evaluated (i) the expression of Ucn 2 and Ucn 3 mRNA in endometriotic lesions and in endometrium of women with endometriosis; (ii) the effect of Ucn 2 and Ucn 3 on cytokines secretion from cultured endometrial stromal cells. Endometriotic tissue was collected from endometrioma (n=39); endometrial specimens were obtained from women with (n=39) and without (n=41) endometriosis throughout menstrual cycle. Tissue specimens were analysed for Ucn 2 and Ucn 3 mRNA expression and peptide localization; the effects of Ucn 2 or Ucn 3 on tumour necrosis factor (TNF-α) and interleukin (IL-4) secretion from cultured endometrial stromal cells was studied. Ucn 2 and Ucn 3 mRNA expression and localization were assessed by RT-PCR and by immuohistochemistry, respectively; cytokines secretion were measured by ELISA. Results showed that endometriotic tissue expressed both Ucn 2 and Ucn 3, with Ucn 3 expression higher in ectopic than in eutopic endometrium. Endometrial Ucn 2 mRNA expression in controls showed peak values at early proliferative phase, while in endometriotic patients low expression and no significant changes throughout menstrual cycle were observed. Endometrial Ucn 3 mRNA expression was highest in late secretory phase in controls, while in endometriotic patients low levels and no menstrual-cycle-related changes were found. When added to cultured endometrial cell cultures, Ucn 2 significantly increased TNF-α (P<0.01) and IL-4 (P<0.001), while Ucn 3 induced an increase of IL-4 secretion (P<0.01). In conclusion, endometriotic tissue expressed and localized Ucn 2 and Ucn 3; patients with endometriosis showed Ucn 2 and Ucn 3 mRNA expression in eutopic endometrium lower than in control group, with no endometrial cycle-related changes. Ucn 2 and Ucn 3-modulated TNF-α and IL-4 secretion from culture endometrial cells. These data suggest a possible involvement of Ucn 2 and Ucn 3 in the mechanisms of endometriosis."xsd:string |
| http://purl.uniprot.org/citations/21454316 | http://purl.org/dc/terms/identifier | "doi:10.1093/molehr/gar020"xsd:string |
| http://purl.uniprot.org/citations/21454316 | http://purl.uniprot.org/core/author | "Piomboni P."xsd:string |
| http://purl.uniprot.org/citations/21454316 | http://purl.uniprot.org/core/author | "Petraglia F."xsd:string |
| http://purl.uniprot.org/citations/21454316 | http://purl.uniprot.org/core/author | "Reis F.M."xsd:string |
| http://purl.uniprot.org/citations/21454316 | http://purl.uniprot.org/core/author | "Florio P."xsd:string |
| http://purl.uniprot.org/citations/21454316 | http://purl.uniprot.org/core/author | "Toti P."xsd:string |
| http://purl.uniprot.org/citations/21454316 | http://purl.uniprot.org/core/author | "Borges L.E."xsd:string |
| http://purl.uniprot.org/citations/21454316 | http://purl.uniprot.org/core/author | "Rocha A.L."xsd:string |
| http://purl.uniprot.org/citations/21454316 | http://purl.uniprot.org/core/author | "Novembri R."xsd:string |
| http://purl.uniprot.org/citations/21454316 | http://purl.uniprot.org/core/author | "Carrarelli P."xsd:string |
| http://purl.uniprot.org/citations/21454316 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21454316 | http://purl.uniprot.org/core/name | "Mol Hum Reprod"xsd:string |
| http://purl.uniprot.org/citations/21454316 | http://purl.uniprot.org/core/pages | "587-593"xsd:string |
| http://purl.uniprot.org/citations/21454316 | http://purl.uniprot.org/core/title | "Urocortin 2 and urocortin 3 in endometriosis: evidence for a possible role in inflammatory response."xsd:string |
| http://purl.uniprot.org/citations/21454316 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/21454316 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21454316 |
| http://purl.uniprot.org/citations/21454316 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21454316 |
| http://purl.uniprot.org/uniprot/#_Q969E3-mappedCitation-21454316 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21454316 |
| http://purl.uniprot.org/uniprot/#_Q96RP3-mappedCitation-21454316 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21454316 |
| http://purl.uniprot.org/uniprot/Q96RP3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21454316 |
| http://purl.uniprot.org/uniprot/Q969E3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21454316 |