| http://purl.uniprot.org/citations/21457704 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21457704 | http://www.w3.org/2000/01/rdf-schema#comment | "KRAS-induced actin-interacting protein (KRAP) was originally characterized as a filamentous-actin-interacting protein. We have recently found that KRAP is an associated molecule with inositol 1,4,5-trisphosphate (IP(3)) receptor (IP(3)R) and is responsible for the proper subcellular localization of IP(3)R. Since it remains unknown whether KRAP regulates the IP(3)R-mediated Ca(2+) signaling, we herein examined the effects of KRAP on the IP(3)R-mediated Ca(2+) release by Ca(2+) imagings in the cultured HEK293 or MCF7 cells. Reduction of KRAP protein by KRAP-specific siRNA diminishes ATP-induced Ca(2+) release and the ATP-induced Ca(2+) release is completely quenched by the pretreatment with the IP(3)R inhibitor but not with the ryanodine receptor inhibitor, indicating that KRAP regulates IP(3)R-mediated Ca(2+) release. To further reveal mechanistic insights into the regulation of IP(3)R-mediated Ca(2+) release by KRAP, we examined the effects of the KRAP-knockdown on the releasable Ca(2+) content of intracellular Ca(2+) stores. Consequently, reduction of KRAP does not affect the amount of ionophore- or Ca(2+)-ATPase inhibitor-induced Ca(2+) release in the HEK293 cells, indicating that releasable Ca(2+) content of intracellular Ca(2+) stores is not altered by KRAP. Thus, KRAP is involved in the proper regulation of IP(3)R-mediated Ca(2+) release."xsd:string |
| http://purl.uniprot.org/citations/21457704 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2011.03.112"xsd:string |
| http://purl.uniprot.org/citations/21457704 | http://purl.uniprot.org/core/author | "Doi K."xsd:string |
| http://purl.uniprot.org/citations/21457704 | http://purl.uniprot.org/core/author | "Ota T."xsd:string |
| http://purl.uniprot.org/citations/21457704 | http://purl.uniprot.org/core/author | "Fujimoto T."xsd:string |
| http://purl.uniprot.org/citations/21457704 | http://purl.uniprot.org/core/author | "Tsunoda T."xsd:string |
| http://purl.uniprot.org/citations/21457704 | http://purl.uniprot.org/core/author | "Machida T."xsd:string |
| http://purl.uniprot.org/citations/21457704 | http://purl.uniprot.org/core/author | "Shirasawa S."xsd:string |
| http://purl.uniprot.org/citations/21457704 | http://purl.uniprot.org/core/author | "Kuroki M."xsd:string |
| http://purl.uniprot.org/citations/21457704 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21457704 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/21457704 | http://purl.uniprot.org/core/pages | "214-217"xsd:string |
| http://purl.uniprot.org/citations/21457704 | http://purl.uniprot.org/core/title | "KRAS-induced actin-interacting protein regulates inositol 1,4,5-trisphosphate-receptor-mediated calcium release."xsd:string |
| http://purl.uniprot.org/citations/21457704 | http://purl.uniprot.org/core/volume | "408"xsd:string |
| http://purl.uniprot.org/citations/21457704 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21457704 |
| http://purl.uniprot.org/citations/21457704 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21457704 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SVN2-mappedCitation-21457704 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21457704 |
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| http://purl.uniprot.org/uniprot/#_A0A0N4SWH7-mappedCitation-21457704 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21457704 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SWI0-mappedCitation-21457704 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21457704 |
| http://purl.uniprot.org/uniprot/#_A0A1D5RLA1-mappedCitation-21457704 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21457704 |
| http://purl.uniprot.org/uniprot/#_E9PHV5-mappedCitation-21457704 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21457704 |
| http://purl.uniprot.org/uniprot/#_A2AQD5-mappedCitation-21457704 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21457704 |
| http://purl.uniprot.org/uniprot/#_A2AQD6-mappedCitation-21457704 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21457704 |