| http://purl.uniprot.org/citations/21460222 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21460222 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21460222 | http://www.w3.org/2000/01/rdf-schema#comment | "Transmembrane adaptor proteins (TRAPs) are important organizers and regulators of immunoreceptor-mediated signaling. A bioinformatic search revealed several potential novel TRAPs, including a highly conserved protein, proline rich 7 (PRR7), previously described as a component of the PSD-95/N-methyl-d-aspartate receptor protein complex in postsynaptic densities (PSD) of rat neurons. Our data demonstrate that PRR7 is weakly expressed in other tissues but is readily up-regulated in activated human peripheral blood lymphocytes. Transient overexpression of PRR7 in Jurkat T cell line led to gradual apoptotic death dependent on the WW domain binding motif surrounding Tyr-166 in the intracellular part of PRR7. To circumvent the pro-apoptotic effect of PRR7, we generated Jurkat clones with inducible expression of PRR7 (J-iPRR7). In these cells acute induction of PRR7 expression had a dual effect. It resulted in up-regulation of the transcription factor c-Jun and the activation marker CD69 as well as enhanced production of IL-2 after phorbol 12-myristate 13-acetate (PMA) and ionomycin treatment. On the other hand, expression of PRR7 inhibited general tyrosine phosphorylation and calcium influx after T cell receptor cross-linking by antibodies. Moreover, we found PRR7 constitutively tyrosine-phosphorylated and associated with Src. Collectively, these data indicate that PRR7 is a potential regulator of signaling and apoptosis in activated T cells."xsd:string |
| http://purl.uniprot.org/citations/21460222 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m110.175117"xsd:string |
| http://purl.uniprot.org/citations/21460222 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m110.175117"xsd:string |
| http://purl.uniprot.org/citations/21460222 | http://purl.uniprot.org/core/author | "Paces J."xsd:string |
| http://purl.uniprot.org/citations/21460222 | http://purl.uniprot.org/core/author | "Paces J."xsd:string |
| http://purl.uniprot.org/citations/21460222 | http://purl.uniprot.org/core/author | "Draber P."xsd:string |
| http://purl.uniprot.org/citations/21460222 | http://purl.uniprot.org/core/author | "Draber P."xsd:string |
| http://purl.uniprot.org/citations/21460222 | http://purl.uniprot.org/core/author | "Angelisova P."xsd:string |
| http://purl.uniprot.org/citations/21460222 | http://purl.uniprot.org/core/author | "Angelisova P."xsd:string |
| http://purl.uniprot.org/citations/21460222 | http://purl.uniprot.org/core/author | "Brdicka T."xsd:string |
| http://purl.uniprot.org/citations/21460222 | http://purl.uniprot.org/core/author | "Brdicka T."xsd:string |
| http://purl.uniprot.org/citations/21460222 | http://purl.uniprot.org/core/author | "Horejsi V."xsd:string |
| http://purl.uniprot.org/citations/21460222 | http://purl.uniprot.org/core/author | "Horejsi V."xsd:string |
| http://purl.uniprot.org/citations/21460222 | http://purl.uniprot.org/core/author | "Hrdinka M."xsd:string |
| http://purl.uniprot.org/citations/21460222 | http://purl.uniprot.org/core/author | "Hrdinka M."xsd:string |
| http://purl.uniprot.org/citations/21460222 | http://purl.uniprot.org/core/author | "Otahal P."xsd:string |
| http://purl.uniprot.org/citations/21460222 | http://purl.uniprot.org/core/author | "Otahal P."xsd:string |
| http://purl.uniprot.org/citations/21460222 | http://purl.uniprot.org/core/author | "Stepanek O."xsd:string |
| http://purl.uniprot.org/citations/21460222 | http://purl.uniprot.org/core/author | "Stepanek O."xsd:string |
| http://purl.uniprot.org/citations/21460222 | http://purl.uniprot.org/core/author | "Drbal K."xsd:string |
| http://purl.uniprot.org/citations/21460222 | http://purl.uniprot.org/core/author | "Drbal K."xsd:string |
| http://purl.uniprot.org/citations/21460222 | http://purl.uniprot.org/core/author | "Ormsby T."xsd:string |
| http://purl.uniprot.org/citations/21460222 | http://purl.uniprot.org/core/author | "Ormsby T."xsd:string |