| http://purl.uniprot.org/citations/21464221 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21464221 | http://www.w3.org/2000/01/rdf-schema#comment | "By studying mice in which the Nfatc1 gene was inactivated in bone marrow, spleen, or germinal center B cells, we show that NFATc1 supports the proliferation and suppresses the activation-induced cell death of splenic B cells upon B cell receptor (BCR) stimulation. BCR triggering leads to expression of NFATc1/αA, a short isoform of NFATc1, in splenic B cells. NFATc1 ablation impaired Ig class switch to IgG3 induced by T cell-independent type II antigens, as well as IgG3(+) plasmablast formation. Mice bearing NFATc1(-/-) B cells harbor twofold more interleukin 10-producing B cells. NFATc1(-/-) B cells suppress the synthesis of interferon-γ by T cells in vitro, and these mice exhibit a mild clinical course of experimental autoimmune encephalomyelitis. In large part, the defective functions of NFATc1(-/-) B cells are caused by decreased BCR-induced Ca(2+) flux and calcineurin (Cn) activation. By affecting CD22, Rcan1, CnA, and NFATc1/αA expression, NFATc1 controls the Ca(2+)-dependent Cn-NFAT signaling network and, thereby, the fate of splenic B cells upon BCR stimulation."xsd:string |
| http://purl.uniprot.org/citations/21464221 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20100945"xsd:string |
| http://purl.uniprot.org/citations/21464221 | http://purl.uniprot.org/core/author | "Chen W."xsd:string |
| http://purl.uniprot.org/citations/21464221 | http://purl.uniprot.org/core/author | "Bhattacharyya S."xsd:string |
| http://purl.uniprot.org/citations/21464221 | http://purl.uniprot.org/core/author | "Lamperti E.D."xsd:string |
| http://purl.uniprot.org/citations/21464221 | http://purl.uniprot.org/core/author | "Engelmann S."xsd:string |
| http://purl.uniprot.org/citations/21464221 | http://purl.uniprot.org/core/author | "Muller M.R."xsd:string |
| http://purl.uniprot.org/citations/21464221 | http://purl.uniprot.org/core/author | "Nitschke L."xsd:string |
| http://purl.uniprot.org/citations/21464221 | http://purl.uniprot.org/core/author | "Berberich-Siebelt F."xsd:string |
| http://purl.uniprot.org/citations/21464221 | http://purl.uniprot.org/core/author | "Brunner C."xsd:string |
| http://purl.uniprot.org/citations/21464221 | http://purl.uniprot.org/core/author | "Schweizer A."xsd:string |
| http://purl.uniprot.org/citations/21464221 | http://purl.uniprot.org/core/author | "Rosenwald A."xsd:string |
| http://purl.uniprot.org/citations/21464221 | http://purl.uniprot.org/core/author | "Kondo E."xsd:string |
| http://purl.uniprot.org/citations/21464221 | http://purl.uniprot.org/core/author | "Jellusova J."xsd:string |
| http://purl.uniprot.org/citations/21464221 | http://purl.uniprot.org/core/author | "Klein-Hessling S."xsd:string |
| http://purl.uniprot.org/citations/21464221 | http://purl.uniprot.org/core/author | "Serfling E."xsd:string |
| http://purl.uniprot.org/citations/21464221 | http://purl.uniprot.org/core/author | "Avots A."xsd:string |
| http://purl.uniprot.org/citations/21464221 | http://purl.uniprot.org/core/author | "Patra A.K."xsd:string |
| http://purl.uniprot.org/citations/21464221 | http://purl.uniprot.org/core/author | "Deb J."xsd:string |
| http://purl.uniprot.org/citations/21464221 | http://purl.uniprot.org/core/author | "Reifenberg K."xsd:string |
| http://purl.uniprot.org/citations/21464221 | http://purl.uniprot.org/core/author | "Bommhardt U."xsd:string |
| http://purl.uniprot.org/citations/21464221 | http://purl.uniprot.org/core/author | "Leich E."xsd:string |
| http://purl.uniprot.org/citations/21464221 | http://purl.uniprot.org/core/author | "Vaeth M."xsd:string |
| http://purl.uniprot.org/citations/21464221 | http://purl.uniprot.org/core/author | "Thuy Pham D.A."xsd:string |