| http://purl.uniprot.org/citations/21464983 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21464983 | http://www.w3.org/2000/01/rdf-schema#comment | "The use of fenfluramines can increase the risk of developing pulmonary arterial hypertension (PAH) in humans, but the mechanisms responsible are unresolved. A recent study reported that female mice lacking the gene for tryptophan hydroxylase-1 (Tph1(-/-) mice) were protected from PAH caused by chronic dexfenfluramine, suggesting a pivotal role for peripheral serotonin (5-HT) in the disease process. Here we tested two alternative hypotheses which might explain the lack of dexfenfluramine-induced PAH in Tph1(-/-) mice. We postulated that: 1) Tph1(-/-) mice express lower levels of pulmonary 5-HT transporter (SERT) when compared to wild-type controls, and 2) Tph1(-/-) mice display adaptive changes in the expression of non-serotonergic pulmonary genes which are implicated in PAH. SERT was measured using radioligand binding methods, whereas gene expression was measured using microarrays followed by quantitative real time PCR (qRT-PCR). Contrary to our first hypothesis, the number of pulmonary SERT sites was modestly up-regulated in female Tph1(-/-) mice. The expression of 51 distinct genes was significantly altered in the lungs of female Tph1(-/-) mice. Consistent with our second hypothesis, qRT-PCR confirmed that at least three genes implicated in the pathogenesis of PAH were markedly up-regulated: Has2, Hapln3 and Retlna. The finding that female Tph1(-/-) mice are protected from dexfenfluramine-induced PAH could be related to compensatory changes in pulmonary gene expression, in addition to reductions in peripheral 5-HT. These observations emphasize the intrinsic limitation of interpreting data from studies conducted in transgenic mice that are not fully characterized."xsd:string |
| http://purl.uniprot.org/citations/21464983 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0017735"xsd:string |
| http://purl.uniprot.org/citations/21464983 | http://purl.uniprot.org/core/author | "Bader M."xsd:string |
| http://purl.uniprot.org/citations/21464983 | http://purl.uniprot.org/core/author | "Alenina N."xsd:string |
| http://purl.uniprot.org/citations/21464983 | http://purl.uniprot.org/core/author | "Becker K.G."xsd:string |
| http://purl.uniprot.org/citations/21464983 | http://purl.uniprot.org/core/author | "Cadet J.L."xsd:string |
| http://purl.uniprot.org/citations/21464983 | http://purl.uniprot.org/core/author | "McCoy M.T."xsd:string |
| http://purl.uniprot.org/citations/21464983 | http://purl.uniprot.org/core/author | "Baumann M.H."xsd:string |
| http://purl.uniprot.org/citations/21464983 | http://purl.uniprot.org/core/author | "Lehrmann E."xsd:string |
| http://purl.uniprot.org/citations/21464983 | http://purl.uniprot.org/core/author | "Rothman R.B."xsd:string |
| http://purl.uniprot.org/citations/21464983 | http://purl.uniprot.org/core/author | "Dersch C.M."xsd:string |
| http://purl.uniprot.org/citations/21464983 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21464983 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/21464983 | http://purl.uniprot.org/core/pages | "e17735"xsd:string |
| http://purl.uniprot.org/citations/21464983 | http://purl.uniprot.org/core/title | "Altered gene expression in pulmonary tissue of tryptophan hydroxylase-1 knockout mice: implications for pulmonary arterial hypertension."xsd:string |
| http://purl.uniprot.org/citations/21464983 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/21464983 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21464983 |
| http://purl.uniprot.org/citations/21464983 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21464983 |
| http://purl.uniprot.org/uniprot/#_E9Q9G5-mappedCitation-21464983 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21464983 |
| http://purl.uniprot.org/uniprot/#_E9Q060-mappedCitation-21464983 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21464983 |
| http://purl.uniprot.org/uniprot/#_D3Z0B1-mappedCitation-21464983 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21464983 |
| http://purl.uniprot.org/uniprot/#_D6RGQ9-mappedCitation-21464983 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21464983 |
| http://purl.uniprot.org/uniprot/#_F6VPB5-mappedCitation-21464983 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21464983 |
| http://purl.uniprot.org/uniprot/#_F7BYX2-mappedCitation-21464983 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21464983 |