| http://purl.uniprot.org/citations/21469128 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21469128 | http://www.w3.org/2000/01/rdf-schema#comment | "Most coinhibitory receptors regulate T-cell responses through an ITIM that recruits protein tyrosine phosphatases (PTPs) to mediate inhibitory function. Because syndecan-4 (SD-4), the coinhibitor for DC-associated heparan sulfate proteoglycan integrin ligand (DC-HIL), lacks such an ITIM, we posited that SD-4 links with a PTP in an ITIM-independent manner. We show that SD-4 associates constitutively with the intracellular protein syntenin but not with the receptor-like PTP CD148 on human CD4(+) T cells. Binding to DC-HIL allowed SD-4 to assemble with CD148 through the help of syntenin as a bridge, and this process upregulated the PTP activity of CD148, which is required for SD-4 to mediate DC-HIL's inhibitory function. Using a mouse model, we found SD-4 to be located away from the immunological synapse formed between T cells and APCs during activation of T cells. These findings indicate that SD-4 is unique among known T-cell coinhibitors, in employing CD148 to inhibit T-cell activation at a site distal from the synapse."xsd:string |
| http://purl.uniprot.org/citations/21469128 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.201041233"xsd:string |
| http://purl.uniprot.org/citations/21469128 | http://purl.uniprot.org/core/author | "Chung J.S."xsd:string |
| http://purl.uniprot.org/citations/21469128 | http://purl.uniprot.org/core/author | "Ariizumi K."xsd:string |
| http://purl.uniprot.org/citations/21469128 | http://purl.uniprot.org/core/author | "Cruz P.D. Jr."xsd:string |
| http://purl.uniprot.org/citations/21469128 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21469128 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/21469128 | http://purl.uniprot.org/core/pages | "1794-1799"xsd:string |
| http://purl.uniprot.org/citations/21469128 | http://purl.uniprot.org/core/title | "Inhibition of T-cell activation by syndecan-4 is mediated by CD148 through protein tyrosine phosphatase activity."xsd:string |
| http://purl.uniprot.org/citations/21469128 | http://purl.uniprot.org/core/volume | "41"xsd:string |
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