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http://purl.uniprot.org/citations/21470206http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/21470206http://www.w3.org/2000/01/rdf-schema#comment"

Background and purpose

In the current study, we investigated the role of both kinin B₁ and B₂ receptors in peripheral neuropathy induced by the chronic treatment of mice with paclitaxel a widely used chemotherapeutic agent.

Experimental approach

Chemotherapy-evoked hyperalgesia was induced by i.p. injections of paclitaxel (2 mg·kg⁻¹) over 5 consecutive days. Mechanical and thermal hyperalgesia were evaluated between 7 and 21 days after the first paclitaxel treatment.

Key results

Treatment with paclitaxel increased both mechanical and thermal hyperalgesia in mice (C57BL/6 and CD1 strains). Kinin receptor deficient mice (B₁, or B₂ receptor knock-out and B₁B₂ receptor, double knock-out) presented a significant reduction in paclitaxel-induced hypernociceptive responses in comparison to wild-type animals. Treatment of CD1 mice with kinin receptor antagonists (DALBK for B₁ or Hoe 140 for B₂ receptors) significantly inhibited both mechanical and thermal hyperalgesia when tested at 7 and 14 days after the first paclitaxel injection. DALBK and Hoe 140 were also effective against paclitaxel-induced peripheral neuropathy when given intrathecally or i.c.v. A marked increase in B₁ receptor mRNA was observed in the mouse thalamus, parietal and pre-frontal cortex from 7 days after the first paclitaxel treatment.

Conclusions and implications

Kinins acting on both B₁ and B₂ receptors, expressed in spinal and supra-spinal sites, played a crucial role in controlling the hypernociceptive state caused by chronic treatment with paclitaxel."xsd:string
http://purl.uniprot.org/citations/21470206http://purl.org/dc/terms/identifier"doi:10.1111/j.1476-5381.2011.01408.x"xsd:string
http://purl.uniprot.org/citations/21470206http://purl.uniprot.org/core/author"Pesquero J.B."xsd:string
http://purl.uniprot.org/citations/21470206http://purl.uniprot.org/core/author"Costa R."xsd:string
http://purl.uniprot.org/citations/21470206http://purl.uniprot.org/core/author"Calixto J.B."xsd:string
http://purl.uniprot.org/citations/21470206http://purl.uniprot.org/core/author"Motta E.M."xsd:string
http://purl.uniprot.org/citations/21470206http://purl.uniprot.org/core/author"Manjavachi M.N."xsd:string
http://purl.uniprot.org/citations/21470206http://purl.uniprot.org/core/author"Bento A.F."xsd:string
http://purl.uniprot.org/citations/21470206http://purl.uniprot.org/core/author"Dutra R.C."xsd:string
http://purl.uniprot.org/citations/21470206http://purl.uniprot.org/core/author"Malinsky F.R."xsd:string
http://purl.uniprot.org/citations/21470206http://purl.uniprot.org/core/date"2011"xsd:gYear
http://purl.uniprot.org/citations/21470206http://purl.uniprot.org/core/name"Br J Pharmacol"xsd:string
http://purl.uniprot.org/citations/21470206http://purl.uniprot.org/core/pages"681-693"xsd:string
http://purl.uniprot.org/citations/21470206http://purl.uniprot.org/core/title"Anti-nociceptive effect of kinin B(1) and B(2) receptor antagonists on peripheral neuropathy induced by paclitaxel in mice."xsd:string
http://purl.uniprot.org/citations/21470206http://purl.uniprot.org/core/volume"164"xsd:string
http://purl.uniprot.org/citations/21470206http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/21470206
http://purl.uniprot.org/citations/21470206http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/21470206
http://purl.uniprot.org/uniprot/#_Q0VBD7-mappedCitation-21470206http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/21470206
http://purl.uniprot.org/uniprot/#_B2RQ47-mappedCitation-21470206http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/21470206
http://purl.uniprot.org/uniprot/#_P32299-mappedCitation-21470206http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/21470206
http://purl.uniprot.org/uniprot/#_Q61125-mappedCitation-21470206http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/21470206
http://purl.uniprot.org/uniprot/B2RQ47http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/21470206
http://purl.uniprot.org/uniprot/P32299http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/21470206
http://purl.uniprot.org/uniprot/Q0VBD7http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/21470206
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