| http://purl.uniprot.org/citations/21470888 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21470888 | http://www.w3.org/2000/01/rdf-schema#comment | "Type 2 diabetes patients exhibit a reduction in oxidative muscle fibres and an increase in glycolytic muscle fibres. In this study, we investigated whether both genetic and non-genetic factors influence the mRNA expression levels of three myosin heavy chain (MHC) genes represented in different fibre types. Specifically, we examined the MHC7 (slow-twitch oxidative fibre), MHCIIa (fast-twitch oxidative fibre) and MHCIIx/d (fast-twitch glycolytic fibre) genes in human skeletal muscle. We further investigated the use of MHC mRNA expression as a proxy to determine fibre-type composition, as measured by traditional ATP staining. Two cohorts of age-matched Swedish men were studied to determine the relationship of muscle mRNA expression of MHC7, MHCIIa, and MHCIIx/d with muscle fibre composition. A classical twin approach, including young and elderly Danish twin pairs, was utilised to examine if differences in expression levels were due to genetic or environmental factors. Although MHCIIx/d mRNA expression correlated positively with the level of type IIx/d muscle fibres in the two cohorts (P<0.05), a relatively low magnitude of correlation suggests that mRNA does not fully correlate with fibre-type composition. Heritability estimates and genetic analysis suggest that the levels of MHC7, MHCIIa and MHCIIx/d expression are primarily under non-genetic influence, and MHCIIa indicated an age-related decline. PGC-1α exhibited a positive relationship with the expression of all three MHC genes (P<0.05); meanwhile, PGC-1β related positively with MHCIIa expression and negatively with MHCIIx/d expression (P<0.05). While MHCIIa expression related positively with insulin-stimulated glucose uptake (P<0.01), MHCIIx/d expression related negatively with insulin-stimulated glucose uptake (P<0.05). Our findings suggest that the expression levels of the MHC genes are associated with age and both PGC-1α and PGC-1β and indicate that the MHC genes may to some extent be used to determine fibre-type composition in human skeletal muscle."xsd:string |
| http://purl.uniprot.org/citations/21470888 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ymgme.2011.03.017"xsd:string |
| http://purl.uniprot.org/citations/21470888 | http://purl.uniprot.org/core/author | "Hansson O."xsd:string |
| http://purl.uniprot.org/citations/21470888 | http://purl.uniprot.org/core/author | "Groop L."xsd:string |
| http://purl.uniprot.org/citations/21470888 | http://purl.uniprot.org/core/author | "Ling C."xsd:string |
| http://purl.uniprot.org/citations/21470888 | http://purl.uniprot.org/core/author | "Poulsen P."xsd:string |
| http://purl.uniprot.org/citations/21470888 | http://purl.uniprot.org/core/author | "Eriksson K.F."xsd:string |
| http://purl.uniprot.org/citations/21470888 | http://purl.uniprot.org/core/author | "Vaag A."xsd:string |
| http://purl.uniprot.org/citations/21470888 | http://purl.uniprot.org/core/author | "Ronn T."xsd:string |
| http://purl.uniprot.org/citations/21470888 | http://purl.uniprot.org/core/author | "Olsson A.H."xsd:string |
| http://purl.uniprot.org/citations/21470888 | http://purl.uniprot.org/core/author | "Elgzyri T."xsd:string |
| http://purl.uniprot.org/citations/21470888 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21470888 | http://purl.uniprot.org/core/name | "Mol Genet Metab"xsd:string |
| http://purl.uniprot.org/citations/21470888 | http://purl.uniprot.org/core/pages | "275-281"xsd:string |
| http://purl.uniprot.org/citations/21470888 | http://purl.uniprot.org/core/title | "The expression of myosin heavy chain (MHC) genes in human skeletal muscle is related to metabolic characteristics involved in the pathogenesis of type 2 diabetes."xsd:string |
| http://purl.uniprot.org/citations/21470888 | http://purl.uniprot.org/core/volume | "103"xsd:string |
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