| http://purl.uniprot.org/citations/21471000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21471000 | http://www.w3.org/2000/01/rdf-schema#comment | "In neurons certain mRNA transcripts are transported to synapses through mechanisms that are not fully understood. Here we report that the heterogeneous nuclear ribonucleoprotein CBF-A (CArG Box binding Factor A) facilitates dendritic transport and localization of activity-regulated cytoskeleton-associated protein (Arc), brain-derived neurotrophic factor (BDNF), and calmodulin-dependent protein kinase II (CaMKIIα) mRNAs. We discovered that, in the adult mouse brain, CBF-A has a broad distribution. In the nucleus, CBF-A was found at active transcription sites and interchromosomal spaces and close to nuclear pores. In the cytoplasm, CBF-A localized to dendrites as well as pre- and postsynaptic sites. CBF-A was found in synaptosomal fractions, associated with Arc, BDNF, and CaMKIIα mRNAs. Electrophoretic mobility shift assays demonstrated a direct interaction mediated via their hnRNP A2 response element (A2RE)/RNA trafficking sequence (RTS) elements located in the 3' untranslated regions. In situ hybridization and microscopy on live hippocampal neurons showed that CBF-A is in dynamic granules containing Arc, BDNF, and CaMKIIα mRNAs. N-methyl-D-aspartate (NMDA) and α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA) postsynaptic receptor stimulation led to CBF-A accumulation in dendrites; increased Arc, BDNF, and CaMKIIα mRNA levels; and increased amounts of transcripts coprecipitating with CBF-A. Finally, CBF-A gene knockdown led to decreased mRNA levels. We propose that CBF-A cotranscriptionally binds RTSs in Arc, BDNF, and CaMKIIα mRNAs and follows the transcripts from genes to dendrites, promoting activity-dependent nuclear sorting of transport-competent mRNAs."xsd:string |
| http://purl.uniprot.org/citations/21471000 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e10-11-0904"xsd:string |
| http://purl.uniprot.org/citations/21471000 | http://purl.uniprot.org/core/author | "Lopez-Iglesias C."xsd:string |
| http://purl.uniprot.org/citations/21471000 | http://purl.uniprot.org/core/author | "Fukuda N."xsd:string |
| http://purl.uniprot.org/citations/21471000 | http://purl.uniprot.org/core/author | "Percipalle P."xsd:string |
| http://purl.uniprot.org/citations/21471000 | http://purl.uniprot.org/core/author | "Visa N."xsd:string |
| http://purl.uniprot.org/citations/21471000 | http://purl.uniprot.org/core/author | "Goritz C."xsd:string |
| http://purl.uniprot.org/citations/21471000 | http://purl.uniprot.org/core/author | "Raju C.S."xsd:string |
| http://purl.uniprot.org/citations/21471000 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21471000 | http://purl.uniprot.org/core/name | "Mol Biol Cell"xsd:string |
| http://purl.uniprot.org/citations/21471000 | http://purl.uniprot.org/core/pages | "1864-1877"xsd:string |
| http://purl.uniprot.org/citations/21471000 | http://purl.uniprot.org/core/title | "In neurons, activity-dependent association of dendritically transported mRNA transcripts with the transacting factor CBF-A is mediated by A2RE/RTS elements."xsd:string |
| http://purl.uniprot.org/citations/21471000 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/21471000 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21471000 |
| http://purl.uniprot.org/citations/21471000 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21471000 |
| http://purl.uniprot.org/uniprot/Q99020#attribution-72C216F386590CC4E030033B4CDFEB02 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21471000 |
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| http://purl.uniprot.org/uniprot/F7F9P3#attribution-B59972C33F34B93307A3E6AA8B7E2997 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21471000 |
| http://purl.uniprot.org/uniprot/F7F9P3#attribution-E5A047442FDEBF6F51547877CFAABB0A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21471000 |
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| http://purl.uniprot.org/uniprot/A0A8J8XXQ6#attribution-E5A047442FDEBF6F51547877CFAABB0A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21471000 |
| http://purl.uniprot.org/uniprot/A6HE59#attribution-2F1AF2B6C045B3B38C1C781D203DAD5F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21471000 |
| http://purl.uniprot.org/uniprot/A6HE59#attribution-B59972C33F34B93307A3E6AA8B7E2997 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21471000 |