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http://purl.uniprot.org/citations/21474455http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/21474455http://www.w3.org/2000/01/rdf-schema#comment"Recently, the anaplastic lymphoma kinase (ALK) has been found to be altered in several solid and hematologic tumors. Novel drugs targeting this tyrosine kinase receptor are under development, and early clinical trials are showing promising activity in non-small cell lung cancer patients with ALK+ tumors. Here, we review the structure and function of the ALK receptor, the mechanisms associated with its deregulation in cancer, methods for ALK detection in tumor samples, its potential as a new marker for candidate patient selection for tailored therapy, and novel drugs under development that target ALK."xsd:string
http://purl.uniprot.org/citations/21474455http://purl.org/dc/terms/identifier"doi:10.1158/1535-7163.mct-10-0615"xsd:string
http://purl.uniprot.org/citations/21474455http://purl.uniprot.org/core/author"Arriola E."xsd:string
http://purl.uniprot.org/citations/21474455http://purl.uniprot.org/core/author"Bolos M.V."xsd:string
http://purl.uniprot.org/citations/21474455http://purl.uniprot.org/core/author"Grande E."xsd:string
http://purl.uniprot.org/citations/21474455http://purl.uniprot.org/core/date"2011"xsd:gYear
http://purl.uniprot.org/citations/21474455http://purl.uniprot.org/core/name"Mol Cancer Ther"xsd:string
http://purl.uniprot.org/citations/21474455http://purl.uniprot.org/core/pages"569-579"xsd:string
http://purl.uniprot.org/citations/21474455http://purl.uniprot.org/core/title"Targeting oncogenic ALK: a promising strategy for cancer treatment."xsd:string
http://purl.uniprot.org/citations/21474455http://purl.uniprot.org/core/volume"10"xsd:string
http://purl.uniprot.org/citations/21474455http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/21474455
http://purl.uniprot.org/citations/21474455http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/21474455
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http://purl.uniprot.org/uniprot/#_B2MXE1-mappedCitation-21474455http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/21474455
http://purl.uniprot.org/uniprot/#_B2MXE2-mappedCitation-21474455http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/21474455
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http://purl.uniprot.org/uniprot/#_B2MXE4-mappedCitation-21474455http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/21474455
http://purl.uniprot.org/uniprot/#_B2MXE5-mappedCitation-21474455http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/21474455