| http://purl.uniprot.org/citations/21478095 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21478095 | http://www.w3.org/2000/01/rdf-schema#comment | "B-cell chronic lymphocytic leukaemia (B-CLL) originates from B lymphocytes that may differ in the activation level, maturation state or cellular subgroups in peripheral blood. Tumour progression in CLL B cells seems to result in gradual accumulation of the clone of resting B lymphocytes in the early phases (G0/G1) of the cell cycle. The G1 phase is impaired in B-CLL. We investigated the gene expression of five key cell cycle regulators: TP 53, c-Myc, cyclin D2, p21WAF1/CIP1 and p27KIP1, which primarily regulate the G1 phase of the cell cycle, or S-phase entry and ultimately control the proliferation and cell growth as well as their role in B-CLL progression. The study was conducted in peripheral blood CLL lymphocytes of 40 previously untreated patients. Statistical analysis of correlations of TP53, cyclin D2, c-Myc, p21WAF1/CIP1 and p27KIP1 expressions in B-CLL patients with different Rai stages demonstrated that the progression of disease was accompanied by increases in p53, cyclin D2 and c-Myc mRNA expression. The expression of p27KIP1 was nearly statistically significant whereas that of p21 WAF1/CIP1 showed no such correlation. Moreover, high expression levels of TP53 and c-Myc genes were found to be closely associated with more aggressive forms of the disease requiring earlier therapy."xsd:string |
| http://purl.uniprot.org/citations/21478095 | http://purl.org/dc/terms/identifier | "doi:10.2478/v10042-010-0048-5"xsd:string |
| http://purl.uniprot.org/citations/21478095 | http://purl.uniprot.org/core/author | "Joanna S."xsd:string |
| http://purl.uniprot.org/citations/21478095 | http://purl.uniprot.org/core/author | "Anna D."xsd:string |
| http://purl.uniprot.org/citations/21478095 | http://purl.uniprot.org/core/author | "Artur P."xsd:string |
| http://purl.uniprot.org/citations/21478095 | http://purl.uniprot.org/core/author | "Barbara M.K."xsd:string |
| http://purl.uniprot.org/citations/21478095 | http://purl.uniprot.org/core/author | "Halina A."xsd:string |
| http://purl.uniprot.org/citations/21478095 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/21478095 | http://purl.uniprot.org/core/name | "Folia Histochem Cytobiol"xsd:string |
| http://purl.uniprot.org/citations/21478095 | http://purl.uniprot.org/core/pages | "534-541"xsd:string |
| http://purl.uniprot.org/citations/21478095 | http://purl.uniprot.org/core/title | "Alterations in TP53, cyclin D2, c-Myc, p21WAF1/CIP1 and p27KIP1 expression associated with progression in B-CLL."xsd:string |
| http://purl.uniprot.org/citations/21478095 | http://purl.uniprot.org/core/volume | "48"xsd:string |
| http://purl.uniprot.org/citations/21478095 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21478095 |
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| http://purl.uniprot.org/uniprot/#_A0A087WXZ1-mappedCitation-21478095 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21478095 |
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| http://purl.uniprot.org/uniprot/#_A0A087X1Q1-mappedCitation-21478095 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21478095 |
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