| http://purl.uniprot.org/citations/21480213 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21480213 | http://www.w3.org/2000/01/rdf-schema#comment | "Rolling leukocytes are exposed to different adhesion molecules and chemokines. Neutrophils rolling on E-selectin induce integrin αLβ2-mediated slow rolling on ICAM-1 by activating a phospholipase C (PLC)γ2-dependent and a separate PI3Kγ-dependent pathway. E-selectin-signaling cooperates with chemokine signaling to recruit neutrophils into inflamed tissues. However, the distal signaling pathway linking PLCγ2 (Plcg2) to αLβ2-activation is unknown. To identify this pathway, we used different Tat-fusion-mutants and gene-deficient mice in intravital microscopy, autoperfused flow chamber, peritonitis, and biochemical studies. We found that the small GTPase Rap1 is activated following E-selectin engagement and that blocking Rap1a in Pik3cg-/-mice by a dominant-negative Tat-fusion mutant completely abolished E-selectin-mediated slow rolling. We identified CalDAG-GEFI (Rasgrp2) and p38 MAPK as key signaling intermediates between PLCγ2 and Rap1a. Gαi-independent leukocyte adhesion to and transmigration through endothelial cells in inflamed postcapillary venules of the cremaster muscle were completely abolished in Rasgrp2-/-mice. The physiological importance of CalDAG-GEFI in E-selectin-dependent integrin activation is shown by complete inhibition of neutrophil recruitment into the inflamed peritoneal cavity of Rasgrp2-/-leukocytes treated with pertussis toxin to block Gαi-signaling. Our data demonstrate that Rap1a activation by p38 MAPK and CalDAG-GEFI is involved in E-selectin-dependent slow rolling and leukocyte recruitment."xsd:string |
| http://purl.uniprot.org/citations/21480213 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.201041196"xsd:string |
| http://purl.uniprot.org/citations/21480213 | http://purl.uniprot.org/core/author | "Mueller H."xsd:string |
| http://purl.uniprot.org/citations/21480213 | http://purl.uniprot.org/core/author | "Laudanna C."xsd:string |
| http://purl.uniprot.org/citations/21480213 | http://purl.uniprot.org/core/author | "Bergmeier W."xsd:string |
| http://purl.uniprot.org/citations/21480213 | http://purl.uniprot.org/core/author | "Wagner D.D."xsd:string |
| http://purl.uniprot.org/citations/21480213 | http://purl.uniprot.org/core/author | "Zarbock A."xsd:string |
| http://purl.uniprot.org/citations/21480213 | http://purl.uniprot.org/core/author | "Ley K."xsd:string |
| http://purl.uniprot.org/citations/21480213 | http://purl.uniprot.org/core/author | "Van Aken H."xsd:string |
| http://purl.uniprot.org/citations/21480213 | http://purl.uniprot.org/core/author | "Bolomini-Vittori M."xsd:string |
| http://purl.uniprot.org/citations/21480213 | http://purl.uniprot.org/core/author | "Stadtmann A."xsd:string |
| http://purl.uniprot.org/citations/21480213 | http://purl.uniprot.org/core/author | "Brinkhaus L."xsd:string |
| http://purl.uniprot.org/citations/21480213 | http://purl.uniprot.org/core/author | "Rossaint J."xsd:string |
| http://purl.uniprot.org/citations/21480213 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21480213 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/21480213 | http://purl.uniprot.org/core/pages | "2074-2085"xsd:string |
| http://purl.uniprot.org/citations/21480213 | http://purl.uniprot.org/core/title | "Rap1a activation by CalDAG-GEFI and p38 MAPK is involved in E-selectin-dependent slow leukocyte rolling."xsd:string |
| http://purl.uniprot.org/citations/21480213 | http://purl.uniprot.org/core/volume | "41"xsd:string |
| http://purl.uniprot.org/citations/21480213 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21480213 |
| http://purl.uniprot.org/citations/21480213 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21480213 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JDL9-mappedCitation-21480213 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21480213 |
| http://purl.uniprot.org/uniprot/#_A0A077S2U6-mappedCitation-21480213 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21480213 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JE52-mappedCitation-21480213 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21480213 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JED9-mappedCitation-21480213 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21480213 |