| http://purl.uniprot.org/citations/21481813 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21481813 | http://www.w3.org/2000/01/rdf-schema#comment | "Lipopolysaccharide (LPS), a structural component of Gram-negative bacteria, is implicated in the pathogenesis of endotoxemia/sepsis and multi-organ injury, including liver damage. We have shown that argininosuccinate synthase (ASS), a hepatic enzyme of the urea cycle, accumulates in circulation within 1h after treatment with both LPS alone and hepatotoxic combination of LPS and D-Galactosamine. These findings indicate ASS as a sensitive biomarker of liver responses to bacterial endotoxin. Furthermore, we suggest that the ASS release represents a potential counteracting liver reaction to LPS, and demonstrates anti-LPS activity of recombinant ASS (rASS) in vitro and in rodent models of endotoxemia in vivo. rASS physically bound to LPS, as indicated by a gel shift assay, and suppressed Escherichia coli growth in cultures consistent with direct antimicrobial properties of ASS. rASS reduced LPS cytotoxicity, TNF-α production, and increased cell viability in cultured mouse macrophages, even when added one hour following LPS challenge. Intraperitoneal injection of rASS (5 mg/kg) after treatment with a high dose of LPS remarkably increased survival of rodents, with a concomitant decrease of sepsis markers TNF-α, C-reactive protein (CRP), and lactate dehydrogenase (LDH) levels in blood. These results suggest that the endogenous ASS constitutes a novel liver-derived component of the innate immune response to bacterial LPS, and that recombinant ASS could mitigate the lethal effects of bacterial endotoxins during sepsis."xsd:string |
| http://purl.uniprot.org/citations/21481813 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.intimp.2011.03.016"xsd:string |
| http://purl.uniprot.org/citations/21481813 | http://purl.uniprot.org/core/author | "Wang A."xsd:string |
| http://purl.uniprot.org/citations/21481813 | http://purl.uniprot.org/core/author | "Wang K.K."xsd:string |
| http://purl.uniprot.org/citations/21481813 | http://purl.uniprot.org/core/author | "Prima V."xsd:string |
| http://purl.uniprot.org/citations/21481813 | http://purl.uniprot.org/core/author | "Molina G."xsd:string |
| http://purl.uniprot.org/citations/21481813 | http://purl.uniprot.org/core/author | "Svetlov S.I."xsd:string |
| http://purl.uniprot.org/citations/21481813 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21481813 | http://purl.uniprot.org/core/name | "Int Immunopharmacol"xsd:string |
| http://purl.uniprot.org/citations/21481813 | http://purl.uniprot.org/core/pages | "1180-1188"xsd:string |
| http://purl.uniprot.org/citations/21481813 | http://purl.uniprot.org/core/title | "Inhibition of LPS toxicity by hepatic argininosuccinate synthase (ASS): novel roles for ASS in innate immune responses to bacterial infection."xsd:string |
| http://purl.uniprot.org/citations/21481813 | http://purl.uniprot.org/core/volume | "11"xsd:string |
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