| http://purl.uniprot.org/citations/21490301 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21490301 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21490301 | http://www.w3.org/2000/01/rdf-schema#comment | "Nucleosome remodeling complexes comprise several large families of chromatin modifiers that integrate multiple epigenetic control signals to play key roles in cell type-specific transcription regulation. We previously isolated a methyl-binding domain protein 2 (MBD2)-containing nucleosome remodeling and deacetylation (NuRD) complex from primary erythroid cells and showed that MBD2 contributes to DNA methylation-dependent embryonic and fetal β-type globin gene silencing during development in vivo. Here we present structural and biophysical details of the coiled-coil interaction between MBD2 and p66α, a critical component of the MBD2-NuRD complex. We show that enforced expression of the isolated p66α coiled-coil domain relieves MBD2-mediated globin gene silencing and that the expressed peptide interacts only with a subset of components of the MBD2-NuRD complex that does not include native p66α or Mi-2. These results demonstrate the central importance of the coiled-coil interaction and suggest that MBD2-dependent DNA methylation-driven gene silencing can be disrupted by selectively targeting this coiled-coil complex."xsd:string |
| http://purl.uniprot.org/citations/21490301 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1015341108"xsd:string |
| http://purl.uniprot.org/citations/21490301 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1015341108"xsd:string |
| http://purl.uniprot.org/citations/21490301 | http://purl.uniprot.org/core/author | "Wang S.Z."xsd:string |
| http://purl.uniprot.org/citations/21490301 | http://purl.uniprot.org/core/author | "Wang S.Z."xsd:string |
| http://purl.uniprot.org/citations/21490301 | http://purl.uniprot.org/core/author | "Scarsdale J.N."xsd:string |
| http://purl.uniprot.org/citations/21490301 | http://purl.uniprot.org/core/author | "Scarsdale J.N."xsd:string |
| http://purl.uniprot.org/citations/21490301 | http://purl.uniprot.org/core/author | "Williams D.C. Jr."xsd:string |
| http://purl.uniprot.org/citations/21490301 | http://purl.uniprot.org/core/author | "Williams D.C. Jr."xsd:string |
| http://purl.uniprot.org/citations/21490301 | http://purl.uniprot.org/core/author | "Desai M.A."xsd:string |
| http://purl.uniprot.org/citations/21490301 | http://purl.uniprot.org/core/author | "Desai M.A."xsd:string |
| http://purl.uniprot.org/citations/21490301 | http://purl.uniprot.org/core/author | "Amaya M.L."xsd:string |
| http://purl.uniprot.org/citations/21490301 | http://purl.uniprot.org/core/author | "Amaya M.L."xsd:string |
| http://purl.uniprot.org/citations/21490301 | http://purl.uniprot.org/core/author | "Ginder G.D."xsd:string |
| http://purl.uniprot.org/citations/21490301 | http://purl.uniprot.org/core/author | "Ginder G.D."xsd:string |
| http://purl.uniprot.org/citations/21490301 | http://purl.uniprot.org/core/author | "Gnanapragasam M.N."xsd:string |
| http://purl.uniprot.org/citations/21490301 | http://purl.uniprot.org/core/author | "Gnanapragasam M.N."xsd:string |
| http://purl.uniprot.org/citations/21490301 | http://purl.uniprot.org/core/author | "Walavalkar N.M."xsd:string |
| http://purl.uniprot.org/citations/21490301 | http://purl.uniprot.org/core/author | "Walavalkar N.M."xsd:string |
| http://purl.uniprot.org/citations/21490301 | http://purl.uniprot.org/core/author | "Webb H.D."xsd:string |
| http://purl.uniprot.org/citations/21490301 | http://purl.uniprot.org/core/author | "Webb H.D."xsd:string |
| http://purl.uniprot.org/citations/21490301 | http://purl.uniprot.org/core/author | "Zu Zhu S."xsd:string |
| http://purl.uniprot.org/citations/21490301 | http://purl.uniprot.org/core/author | "Zu Zhu S."xsd:string |