| http://purl.uniprot.org/citations/21490601 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21490601 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21490601 | http://www.w3.org/2000/01/rdf-schema#comment | "Enzymes catalysing the methylation of the 5-position of cytosine (mC) have essential roles in regulating gene expression and maintaining cellular identity. Recently, TET1 was found to hydroxylate the methyl group of mC, converting it to 5-hydroxymethyl cytosine (hmC). Here we show that TET1 binds throughout the genome of embryonic stem cells, with the majority of binding sites located at transcription start sites (TSSs) of CpG-rich promoters and within genes. The hmC modification is found in gene bodies and in contrast to mC is also enriched at CpG-rich TSSs. We provide evidence further that TET1 has a role in transcriptional repression. TET1 binds a significant proportion of Polycomb group target genes. Furthermore, TET1 associates and colocalizes with the SIN3A co-repressor complex. We propose that TET1 fine-tunes transcription, opposes aberrant DNA methylation at CpG-rich sequences and thereby contributes to the regulation of DNA methylation fidelity."xsd:string |
| http://purl.uniprot.org/citations/21490601 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature10066"xsd:string |
| http://purl.uniprot.org/citations/21490601 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature10066"xsd:string |
| http://purl.uniprot.org/citations/21490601 | http://purl.uniprot.org/core/author | "Christensen J."xsd:string |
| http://purl.uniprot.org/citations/21490601 | http://purl.uniprot.org/core/author | "Christensen J."xsd:string |
| http://purl.uniprot.org/citations/21490601 | http://purl.uniprot.org/core/author | "Williams K."xsd:string |
| http://purl.uniprot.org/citations/21490601 | http://purl.uniprot.org/core/author | "Williams K."xsd:string |
| http://purl.uniprot.org/citations/21490601 | http://purl.uniprot.org/core/author | "Rappsilber J."xsd:string |
| http://purl.uniprot.org/citations/21490601 | http://purl.uniprot.org/core/author | "Rappsilber J."xsd:string |
| http://purl.uniprot.org/citations/21490601 | http://purl.uniprot.org/core/author | "Helin K."xsd:string |
| http://purl.uniprot.org/citations/21490601 | http://purl.uniprot.org/core/author | "Helin K."xsd:string |
| http://purl.uniprot.org/citations/21490601 | http://purl.uniprot.org/core/author | "Johansen J.V."xsd:string |
| http://purl.uniprot.org/citations/21490601 | http://purl.uniprot.org/core/author | "Johansen J.V."xsd:string |
| http://purl.uniprot.org/citations/21490601 | http://purl.uniprot.org/core/author | "Cloos P.A."xsd:string |
| http://purl.uniprot.org/citations/21490601 | http://purl.uniprot.org/core/author | "Cloos P.A."xsd:string |
| http://purl.uniprot.org/citations/21490601 | http://purl.uniprot.org/core/author | "Pedersen M.T."xsd:string |
| http://purl.uniprot.org/citations/21490601 | http://purl.uniprot.org/core/author | "Pedersen M.T."xsd:string |
| http://purl.uniprot.org/citations/21490601 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21490601 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21490601 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/21490601 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/21490601 | http://purl.uniprot.org/core/pages | "343-348"xsd:string |
| http://purl.uniprot.org/citations/21490601 | http://purl.uniprot.org/core/pages | "343-348"xsd:string |