| http://purl.uniprot.org/citations/21490930 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21490930 | http://www.w3.org/2000/01/rdf-schema#comment | "Seven-transmembrane receptors typically mediate olfactory signal transduction by coupling to G-proteins. Although insect odorant receptors have seven transmembrane domains like G-protein coupled receptors, they have an inverted membrane topology, constituting a key difference between the olfactory systems of insects and other animals. While heteromeric insect ORs form ligand-activated non-selective cation channels in recombinant expression systems, the evidence for an involvement of cyclic nucleotides and G-proteins in odor reception is inconsistent. We addressed this question in vivo by analyzing the role of G-proteins in olfactory signaling using electrophysiological recordings. We found that Gα(s) plays a crucial role for odorant induced signal transduction in OR83b expressing olfactory sensory neurons, but not in neurons expressing CO₂ responsive proteins GR21a/GR63a. Moreover, signaling of Drosophila ORs involved Gα(s) also in a heterologous expression system. In agreement with these observations was the finding that elevated levels of cAMP result in increased firing rates, demonstrating the existence of a cAMP dependent excitatory signaling pathway in the sensory neurons. Together, we provide evidence that Gα(s) plays a role in the OR mediated signaling cascade in Drosophila."xsd:string |
| http://purl.uniprot.org/citations/21490930 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0018605"xsd:string |
| http://purl.uniprot.org/citations/21490930 | http://purl.uniprot.org/core/author | "Deng Y."xsd:string |
| http://purl.uniprot.org/citations/21490930 | http://purl.uniprot.org/core/author | "Zhang W."xsd:string |
| http://purl.uniprot.org/citations/21490930 | http://purl.uniprot.org/core/author | "Neuhaus E.M."xsd:string |
| http://purl.uniprot.org/citations/21490930 | http://purl.uniprot.org/core/author | "Gisselmann G."xsd:string |
| http://purl.uniprot.org/citations/21490930 | http://purl.uniprot.org/core/author | "Farhat K."xsd:string |
| http://purl.uniprot.org/citations/21490930 | http://purl.uniprot.org/core/author | "Oberland S."xsd:string |
| http://purl.uniprot.org/citations/21490930 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21490930 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/21490930 | http://purl.uniprot.org/core/pages | "e18605"xsd:string |
| http://purl.uniprot.org/citations/21490930 | http://purl.uniprot.org/core/title | "The stimulatory Galpha(s) protein is involved in olfactory signal transduction in Drosophila."xsd:string |
| http://purl.uniprot.org/citations/21490930 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/21490930 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21490930 |
| http://purl.uniprot.org/citations/21490930 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21490930 |
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