| http://purl.uniprot.org/citations/21497766 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21497766 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21497766 | http://www.w3.org/2000/01/rdf-schema#comment | "Centrioles play a crucial role in mitotic spindle assembly and duplicate precisely once per cell cycle. In worms, flies, and humans, centriole assembly is dependent upon a key regulatory kinase (ZYG-1/Sak/Plk4) and its downstream effectors SAS-5 and SAS-6. Here we report a role for protein phosphatase 2A (PP2A) in centriole duplication. We find that the PP2A catalytic subunit LET-92, the scaffolding subunit PAA-1, and the B55 regulatory subunit SUR-6 function together to positively regulate centriole assembly. In PP2A-SUR-6-depleted embryos, the levels of ZYG-1 and SAS-5 are reduced and the ZYG-1- and SAS-5-dependent recruitment of SAS-6 to the nascent centriole fails. We show that PP2A physically associates with SAS-5 in vivo and that inhibiting proteolysis can rescue SAS-5 levels and the centriole duplication defect of PP2A-depleted embryos. Together, our findings indicate that PP2A-SUR-6 promotes centriole assembly by protecting ZYG-1 and SAS-5 from degradation."xsd:string |
| http://purl.uniprot.org/citations/21497766 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2011.03.007"xsd:string |
| http://purl.uniprot.org/citations/21497766 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2011.03.007"xsd:string |
| http://purl.uniprot.org/citations/21497766 | http://purl.uniprot.org/core/author | "Anderson D.E."xsd:string |
| http://purl.uniprot.org/citations/21497766 | http://purl.uniprot.org/core/author | "Anderson D.E."xsd:string |
| http://purl.uniprot.org/citations/21497766 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/21497766 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/21497766 | http://purl.uniprot.org/core/author | "Jahng W.J."xsd:string |
| http://purl.uniprot.org/citations/21497766 | http://purl.uniprot.org/core/author | "Jahng W.J."xsd:string |
| http://purl.uniprot.org/citations/21497766 | http://purl.uniprot.org/core/author | "O'Connell K.F."xsd:string |
| http://purl.uniprot.org/citations/21497766 | http://purl.uniprot.org/core/author | "O'Connell K.F."xsd:string |
| http://purl.uniprot.org/citations/21497766 | http://purl.uniprot.org/core/author | "Song M.H."xsd:string |
| http://purl.uniprot.org/citations/21497766 | http://purl.uniprot.org/core/author | "Song M.H."xsd:string |
| http://purl.uniprot.org/citations/21497766 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21497766 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21497766 | http://purl.uniprot.org/core/name | "Dev. Cell"xsd:string |
| http://purl.uniprot.org/citations/21497766 | http://purl.uniprot.org/core/name | "Dev. Cell"xsd:string |
| http://purl.uniprot.org/citations/21497766 | http://purl.uniprot.org/core/pages | "563-571"xsd:string |
| http://purl.uniprot.org/citations/21497766 | http://purl.uniprot.org/core/pages | "563-571"xsd:string |
| http://purl.uniprot.org/citations/21497766 | http://purl.uniprot.org/core/title | "Protein phosphatase 2A-SUR-6/B55 regulates centriole duplication in C. elegans by controlling the levels of centriole assembly factors."xsd:string |
| http://purl.uniprot.org/citations/21497766 | http://purl.uniprot.org/core/title | "Protein phosphatase 2A-SUR-6/B55 regulates centriole duplication in C. elegans by controlling the levels of centriole assembly factors."xsd:string |
| http://purl.uniprot.org/citations/21497766 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/21497766 | http://purl.uniprot.org/core/volume | "20"xsd:string |