| http://purl.uniprot.org/citations/21499248 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21499248 | http://www.w3.org/2000/01/rdf-schema#comment | "To identify the genetic susceptibility factor(s) for hepatitis C virus-induced hepatocellular carcinoma (HCV-induced HCC), we conducted a genome-wide association study using 432,703 autosomal SNPs in 721 individuals with HCV-induced HCC (cases) and 2,890 HCV-negative controls of Japanese origin. Eight SNPs that showed possible association (P < 1 × 10(-5)) in the genome-wide association study were further genotyped in 673 cases and 2,596 controls. We found a previously unidentified locus in the 5' flanking region of MICA on 6p21.33 (rs2596542, P(combined) = 4.21 × 10(-13), odds ratio = 1.39) to be strongly associated with HCV-induced HCC. Subsequent analyses using individuals with chronic hepatitis C (CHC) indicated that this SNP is not associated with CHC susceptibility (P = 0.61) but is significantly associated with progression from CHC to HCC (P = 3.13 × 10(-8)). We also found that the risk allele of rs2596542 was associated with lower soluble MICA protein levels in individuals with HCV-induced HCC (P = 1.38 × 10(-13))."xsd:string |
| http://purl.uniprot.org/citations/21499248 | http://purl.org/dc/terms/identifier | "doi:10.1038/ng.809"xsd:string |
| http://purl.uniprot.org/citations/21499248 | http://purl.uniprot.org/core/author | "Kato N."xsd:string |
| http://purl.uniprot.org/citations/21499248 | http://purl.uniprot.org/core/author | "Kubo M."xsd:string |
| http://purl.uniprot.org/citations/21499248 | http://purl.uniprot.org/core/author | "Nakamura Y."xsd:string |
| http://purl.uniprot.org/citations/21499248 | http://purl.uniprot.org/core/author | "Nakagawa H."xsd:string |
| http://purl.uniprot.org/citations/21499248 | http://purl.uniprot.org/core/author | "Matsuda K."xsd:string |
| http://purl.uniprot.org/citations/21499248 | http://purl.uniprot.org/core/author | "Urabe Y."xsd:string |
| http://purl.uniprot.org/citations/21499248 | http://purl.uniprot.org/core/author | "Kumar V."xsd:string |
| http://purl.uniprot.org/citations/21499248 | http://purl.uniprot.org/core/author | "Takahashi A."xsd:string |
| http://purl.uniprot.org/citations/21499248 | http://purl.uniprot.org/core/author | "Kamatani N."xsd:string |
| http://purl.uniprot.org/citations/21499248 | http://purl.uniprot.org/core/author | "Otsuka M."xsd:string |
| http://purl.uniprot.org/citations/21499248 | http://purl.uniprot.org/core/author | "Omata M."xsd:string |
| http://purl.uniprot.org/citations/21499248 | http://purl.uniprot.org/core/author | "Koike K."xsd:string |
| http://purl.uniprot.org/citations/21499248 | http://purl.uniprot.org/core/author | "Hosono N."xsd:string |
| http://purl.uniprot.org/citations/21499248 | http://purl.uniprot.org/core/author | "Muroyama R."xsd:string |
| http://purl.uniprot.org/citations/21499248 | http://purl.uniprot.org/core/author | "Tateishi R."xsd:string |
| http://purl.uniprot.org/citations/21499248 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21499248 | http://purl.uniprot.org/core/name | "Nat Genet"xsd:string |
| http://purl.uniprot.org/citations/21499248 | http://purl.uniprot.org/core/pages | "455-458"xsd:string |
| http://purl.uniprot.org/citations/21499248 | http://purl.uniprot.org/core/title | "Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma."xsd:string |
| http://purl.uniprot.org/citations/21499248 | http://purl.uniprot.org/core/volume | "43"xsd:string |
| http://purl.uniprot.org/citations/21499248 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21499248 |
| http://purl.uniprot.org/citations/21499248 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21499248 |