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| http://purl.uniprot.org/citations/21502406 | http://www.w3.org/2000/01/rdf-schema#comment | "The large genomes of eukaryotic cells are replicated from multiple replication origins during S phase of the cell cycle. These origins are not activated synchronously at the beginning of S phase but, instead, fire throughout S phase according to a predetermined, cell-type-specific program. Ensuring that each origin is efficiently activated once and only once during each S phase is crucial for maintaining the integrity of the genome. This is achieved by a two-step mechanism. The first step, licensing, involves the loading of the Mcm2-7 proteins into pre-replicative complexes (pre-RCs) at origins by ORC, Cdc6, and Cdt1. Pre-RCs can only assemble at origins during G(1) phase, when cyclin-dependent kinase (CDK) activity is low because CDKs inhibit each pre-RC component individually. CDKs trigger initiation by phosphorylating two essential proteins, Sld2 and Sld3. A second protein kinase, Cdc7, along with its regulatory subunit, Dbf4, is also required for initiation. In response to DNA damage, origin firing is inhibited by a third protein kinase, Rad53, which phosphorylates and inhibits Sld3 and Dbf4. In this chapter, I describe these regulatory mechanisms in detail and explore the role of redundancy in the regulation of DNA replication, focusing on the budding yeast, Saccharomyces cerevisiae."xsd:string |
| http://purl.uniprot.org/citations/21502406 | http://purl.org/dc/terms/identifier | "doi:10.1101/sqb.2010.75.062"xsd:string |
| http://purl.uniprot.org/citations/21502406 | http://purl.uniprot.org/core/author | "Diffley J.F."xsd:string |
| http://purl.uniprot.org/citations/21502406 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/21502406 | http://purl.uniprot.org/core/name | "Cold Spring Harb Symp Quant Biol"xsd:string |
| http://purl.uniprot.org/citations/21502406 | http://purl.uniprot.org/core/pages | "135-142"xsd:string |
| http://purl.uniprot.org/citations/21502406 | http://purl.uniprot.org/core/title | "The many faces of redundancy in DNA replication control."xsd:string |
| http://purl.uniprot.org/citations/21502406 | http://purl.uniprot.org/core/volume | "75"xsd:string |
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