| http://purl.uniprot.org/citations/21505262 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21505262 | http://www.w3.org/2000/01/rdf-schema#comment | "Type 1 diabetes is a chronic autoimmune disease in which genetic predispositions affect the immune system, leading to a loss of T cell tolerance to β cells and consequent T cell-mediated destruction of insulin-producing islet cells. Genetic studies have suggested that PRSS16 is linked to a diabetes susceptibility locus of the extended HLA class I region in humans. PRSS16 encodes what we believe to be a novel protease, thymus-specific serine protease (TSSP), which shows predominant expression in thymic epithelial cells and is suspected to have a restricted role in the class II presentation pathway. Consistently, Tssp is necessary for the intrathymic selection of few class II-restricted T cell receptor specificities in B6 mice. To directly assess the role of Tssp in autoimmune diabetes, we generated Tssp-deficient (Tssp°) NOD mice. While remaining immunocompetent, Tssp° NOD mice were protected from diabetes and severe insulitis. Diabetes resistance of Tssp° NOD mice was a property of the CD4 T cell compartment that is acquired during thymic selection and correlated with an impaired selection of CD4 T cells specific for islet antigens. Hence, in the NOD mouse, Tssp is a critical regulator of diabetes development through the selection of the autoreactive CD4 T cell repertoire."xsd:string |
| http://purl.uniprot.org/citations/21505262 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci43314"xsd:string |
| http://purl.uniprot.org/citations/21505262 | http://purl.uniprot.org/core/author | "Serre L."xsd:string |
| http://purl.uniprot.org/citations/21505262 | http://purl.uniprot.org/core/author | "Vignali D.A."xsd:string |
| http://purl.uniprot.org/citations/21505262 | http://purl.uniprot.org/core/author | "Carrier A."xsd:string |
| http://purl.uniprot.org/citations/21505262 | http://purl.uniprot.org/core/author | "Viret C."xsd:string |
| http://purl.uniprot.org/citations/21505262 | http://purl.uniprot.org/core/author | "Malissen B."xsd:string |
| http://purl.uniprot.org/citations/21505262 | http://purl.uniprot.org/core/author | "Guerder S."xsd:string |
| http://purl.uniprot.org/citations/21505262 | http://purl.uniprot.org/core/author | "Leung-Theung-Long S."xsd:string |
| http://purl.uniprot.org/citations/21505262 | http://purl.uniprot.org/core/author | "Lamare C."xsd:string |
| http://purl.uniprot.org/citations/21505262 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21505262 | http://purl.uniprot.org/core/name | "J Clin Invest"xsd:string |
| http://purl.uniprot.org/citations/21505262 | http://purl.uniprot.org/core/pages | "1810-1821"xsd:string |
| http://purl.uniprot.org/citations/21505262 | http://purl.uniprot.org/core/title | "Thymus-specific serine protease controls autoreactive CD4 T cell development and autoimmune diabetes in mice."xsd:string |
| http://purl.uniprot.org/citations/21505262 | http://purl.uniprot.org/core/volume | "121"xsd:string |
| http://purl.uniprot.org/citations/21505262 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21505262 |
| http://purl.uniprot.org/citations/21505262 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21505262 |
| http://purl.uniprot.org/uniprot/#_A0A286YCE6-mappedCitation-21505262 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21505262 |
| http://purl.uniprot.org/uniprot/#_P01849-mappedCitation-21505262 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21505262 |
| http://purl.uniprot.org/uniprot/#_P97313-mappedCitation-21505262 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21505262 |
| http://purl.uniprot.org/uniprot/#_Q5SZ30-mappedCitation-21505262 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21505262 |
| http://purl.uniprot.org/uniprot/#_Q9QXE5-mappedCitation-21505262 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21505262 |
| http://purl.uniprot.org/uniprot/P97313 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21505262 |
| http://purl.uniprot.org/uniprot/P01849 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21505262 |