| http://purl.uniprot.org/citations/21508132 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21508132 | http://www.w3.org/2000/01/rdf-schema#comment | "Context and objectiveGH has positive cognitive effects when given to GH-IGF-I-deficient patients. GH and IGF-I exert both neuroprotective and regenerative effects on experimental stroke. We investigated whether the endogenous serum IGF-I (s-IGF-I) levels correlated with recovery of functional independence in patients who had suffered an ischemic stroke.Subjects and methodsThe s-IGF-I levels were measured in 407 patients (260 males, 147 females) with mean age of 55 (range, 18-69) yr and 40 randomly selected matched controls who were previously included in the Sahlgrenska Academy Study on Ischemic Stroke. Serum samples were collected on two occasions: acutely at 1-10 d (median, 4 d) after stroke and 3 months after the stroke. Recovery after ischemic stroke was evaluated using the modified Rankin scale 3 and 24 months after the stroke, and the Scandinavian Stroke Scale was used for assessments during the acute stage and 3 months after the stroke.ResultsThe s-IGF-I levels were higher in the acute stage than after 3 months and compared with the controls (P < 0.001 and P < 0.01, respectively), and the s-IGF-I levels were progressively lower in the elderly patients. The levels of s-IGF-I in the acute phase and after 3 months both positively correlated with improvement in the modified Rankin scale scores between 3 and 24 months (P = 0.001; r = 0.174, and P < 0.001; r = 0.24, respectively).ConclusionA high s-IGF-I during the rehabilitation phase of stroke correlates to better recovery of long-term function."xsd:string |
| http://purl.uniprot.org/citations/21508132 | http://purl.org/dc/terms/identifier | "doi:10.1210/jc.2010-2802"xsd:string |
| http://purl.uniprot.org/citations/21508132 | http://purl.uniprot.org/core/author | "Nilsson M."xsd:string |
| http://purl.uniprot.org/citations/21508132 | http://purl.uniprot.org/core/author | "Jern C."xsd:string |
| http://purl.uniprot.org/citations/21508132 | http://purl.uniprot.org/core/author | "Isgaard J."xsd:string |
| http://purl.uniprot.org/citations/21508132 | http://purl.uniprot.org/core/author | "Blomstrand C."xsd:string |
| http://purl.uniprot.org/citations/21508132 | http://purl.uniprot.org/core/author | "Aberg N.D."xsd:string |
| http://purl.uniprot.org/citations/21508132 | http://purl.uniprot.org/core/author | "Jood K."xsd:string |
| http://purl.uniprot.org/citations/21508132 | http://purl.uniprot.org/core/author | "Aberg D."xsd:string |
| http://purl.uniprot.org/citations/21508132 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21508132 | http://purl.uniprot.org/core/name | "J Clin Endocrinol Metab"xsd:string |
| http://purl.uniprot.org/citations/21508132 | http://purl.uniprot.org/core/pages | "E1055-64"xsd:string |
| http://purl.uniprot.org/citations/21508132 | http://purl.uniprot.org/core/title | "Serum IGF-I levels correlate to improvement of functional outcome after ischemic stroke."xsd:string |
| http://purl.uniprot.org/citations/21508132 | http://purl.uniprot.org/core/volume | "96"xsd:string |
| http://purl.uniprot.org/citations/21508132 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21508132 |
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