| http://purl.uniprot.org/citations/21508258 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21508258 | http://www.w3.org/2000/01/rdf-schema#comment | "Notch3 overexpression has been previously shown to positively regulate the generation and function of naturally occurring regulatory T cells and the expression of Foxp3, in cooperation with the pTα/pre-TCR pathway. In this study, we show that Notch3 triggers the trans activation of Foxp3 promoter depending on the T cell developmental stage. Moreover, we discovered a novel CSL/NF-κB overlapping binding site within the Foxp3 promoter, and we demonstrate that the activation of NF-κB, mainly represented by p65-dependent canonical pathway, plays a positive role in Notch3-dependent regulation of Foxp3 transcription. Accordingly, the deletion of protein kinase C, which mediates canonical NF-κB activation, markedly reduces regulatory T cell number and per cell Foxp3 expression in transgenic mice with a constitutive activation of Notch3 signaling. Collectively, our data indicate that the cooperation among Notch3, protein kinase C, and p65/NF-κB subunit modulates Foxp3 expression, adding new insights in the understanding of the molecular mechanisms involved in regulatory T cell homeostasis and function."xsd:string |
| http://purl.uniprot.org/citations/21508258 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1002136"xsd:string |
| http://purl.uniprot.org/citations/21508258 | http://purl.uniprot.org/core/author | "Frati L."xsd:string |
| http://purl.uniprot.org/citations/21508258 | http://purl.uniprot.org/core/author | "Screpanti I."xsd:string |
| http://purl.uniprot.org/citations/21508258 | http://purl.uniprot.org/core/author | "Bellavia D."xsd:string |
| http://purl.uniprot.org/citations/21508258 | http://purl.uniprot.org/core/author | "Gulino A."xsd:string |
| http://purl.uniprot.org/citations/21508258 | http://purl.uniprot.org/core/author | "Vacca A."xsd:string |
| http://purl.uniprot.org/citations/21508258 | http://purl.uniprot.org/core/author | "Campese A.F."xsd:string |
| http://purl.uniprot.org/citations/21508258 | http://purl.uniprot.org/core/author | "Felli M.P."xsd:string |
| http://purl.uniprot.org/citations/21508258 | http://purl.uniprot.org/core/author | "Di Mario G."xsd:string |
| http://purl.uniprot.org/citations/21508258 | http://purl.uniprot.org/core/author | "Grazioli P."xsd:string |
| http://purl.uniprot.org/citations/21508258 | http://purl.uniprot.org/core/author | "Colantoni S."xsd:string |
| http://purl.uniprot.org/citations/21508258 | http://purl.uniprot.org/core/author | "Barbarulo A."xsd:string |
| http://purl.uniprot.org/citations/21508258 | http://purl.uniprot.org/core/author | "Ciuffetta A."xsd:string |
| http://purl.uniprot.org/citations/21508258 | http://purl.uniprot.org/core/author | "Pelullo M."xsd:string |
| http://purl.uniprot.org/citations/21508258 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21508258 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/21508258 | http://purl.uniprot.org/core/pages | "6199-6206"xsd:string |
| http://purl.uniprot.org/citations/21508258 | http://purl.uniprot.org/core/title | "Notch3 and canonical NF-kappaB signaling pathways cooperatively regulate Foxp3 transcription."xsd:string |
| http://purl.uniprot.org/citations/21508258 | http://purl.uniprot.org/core/volume | "186"xsd:string |
| http://purl.uniprot.org/citations/21508258 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21508258 |
| http://purl.uniprot.org/citations/21508258 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21508258 |
| http://purl.uniprot.org/uniprot/#_A4L9Q2-mappedCitation-21508258 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21508258 |
| http://purl.uniprot.org/uniprot/#_A0A494B901-mappedCitation-21508258 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21508258 |