| http://purl.uniprot.org/citations/21508316 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21508316 | http://www.w3.org/2000/01/rdf-schema#comment | "Adherens and tight junctions play key roles in assembling epithelia and maintaining barriers. In cell culture zonula occludens (ZO)-family proteins are important for assembly/maturation of both tight and adherens junctions (AJs). Genetic studies suggest that ZO proteins are important during normal development, but interpretation of mouse and fly studies is limited by genetic redundancy and/or a lack of null alleles. We generated null alleles of the single Drosophila ZO protein Polychaetoid (Pyd). Most embryos lacking Pyd die with striking defects in morphogenesis of embryonic epithelia including the epidermis, segmental grooves, and tracheal system. Pyd loss does not dramatically affect AJ protein localization or initial localization of actin and myosin during dorsal closure. However, Pyd loss does affect several cell behaviors that drive dorsal closure. The defects, which include segmental grooves that fail to retract, a disrupted leading edge actin cable, and reduced zippering as leading edges meet, closely resemble defects in canoe zygotic null mutants and in embryos lacking the actin regulator Enabled (Ena), suggesting that these proteins act together. Canoe (Cno) and Pyd are required for proper Ena localization during dorsal closure, and strong genetic interactions suggest that Cno, Pyd, and Ena act together in regulating or anchoring the actin cytoskeleton during dorsal closure."xsd:string |
| http://purl.uniprot.org/citations/21508316 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e10-12-1014"xsd:string |
| http://purl.uniprot.org/citations/21508316 | http://purl.uniprot.org/core/author | "Jung K.C."xsd:string |
| http://purl.uniprot.org/citations/21508316 | http://purl.uniprot.org/core/author | "Peifer M."xsd:string |
| http://purl.uniprot.org/citations/21508316 | http://purl.uniprot.org/core/author | "Bhat M.A."xsd:string |
| http://purl.uniprot.org/citations/21508316 | http://purl.uniprot.org/core/author | "Choi W."xsd:string |
| http://purl.uniprot.org/citations/21508316 | http://purl.uniprot.org/core/author | "Fanning A.S."xsd:string |
| http://purl.uniprot.org/citations/21508316 | http://purl.uniprot.org/core/author | "Beitel G.J."xsd:string |
| http://purl.uniprot.org/citations/21508316 | http://purl.uniprot.org/core/author | "Nelson K.S."xsd:string |
| http://purl.uniprot.org/citations/21508316 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21508316 | http://purl.uniprot.org/core/name | "Mol Biol Cell"xsd:string |
| http://purl.uniprot.org/citations/21508316 | http://purl.uniprot.org/core/pages | "2010-2030"xsd:string |
| http://purl.uniprot.org/citations/21508316 | http://purl.uniprot.org/core/title | "The single Drosophila ZO-1 protein Polychaetoid regulates embryonic morphogenesis in coordination with Canoe/afadin and Enabled."xsd:string |
| http://purl.uniprot.org/citations/21508316 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/21508316 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21508316 |
| http://purl.uniprot.org/citations/21508316 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21508316 |
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| http://purl.uniprot.org/uniprot/Q9VHK1#attribution-991E837864BEA8AE8CE9F7537E71D64A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21508316 |
| http://purl.uniprot.org/uniprot/Q94880#attribution-991E837864BEA8AE8CE9F7537E71D64A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21508316 |
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| http://purl.uniprot.org/uniprot/Q9VHK3#attribution-991E837864BEA8AE8CE9F7537E71D64A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21508316 |