DESCRIBE <http://purl.uniprot.org/citations/21508375>

Subject	Predicate	Object
http://purl.uniprot.org/citations/21508375	http://www.w3.org/1999/02/22-rdf-syntax-ns#type	http://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/21508375	http://www.w3.org/2000/01/rdf-schema#comment	" Background Claudin-4, a component of the tight junction, plays an important role in tumorigenesis and metastasis of ovarian cancer, but its role in platinum resistance has not been elucidated. Materials and methods Claudin-4 expression in ovarian cancer cells was inhibited and the changes in cisplatin sensitivity were examined. Fluorescence-labeled cisplatin was used to examine whether inhibition of claudin-4 changed the cellular accumulation of cisplatin. Claudin-4 expression in ovarian cancer tissue resected from the patients surgically was evaluated immunohistochemically. Results Suppression of claudin-4 resulted in a significant increase of cisplatin sensitivity and cellular accumulation of fluorescence-labeled cisplatin. Claudin-4 expression was significantly greater in ovarian cancer tissue from chemoresistant patients compared to chemosensitive patients. The overall survival was significantly shorter for claudin-4-positive than claudin-4-negative cases. Conclusion These data suggest that claudin-4 contributes to platinum resistance in ovarian cancer and may be a potential target in the treatment of platinum-resistant tumors."xsd:string
http://purl.uniprot.org/citations/21508375	http://purl.uniprot.org/core/author	"Yoshida H."xsd:string
http://purl.uniprot.org/citations/21508375	http://purl.uniprot.org/core/author	"Honda K."xsd:string
http://purl.uniprot.org/citations/21508375	http://purl.uniprot.org/core/author	"Yasui T."xsd:string
http://purl.uniprot.org/citations/21508375	http://purl.uniprot.org/core/author	"Zhi X."xsd:string
http://purl.uniprot.org/citations/21508375	http://purl.uniprot.org/core/author	"Sumi T."xsd:string
http://purl.uniprot.org/citations/21508375	http://purl.uniprot.org/core/author	"Ishiko O."xsd:string
http://purl.uniprot.org/citations/21508375	http://purl.uniprot.org/core/date	"2011"xsd:gYear
http://purl.uniprot.org/citations/21508375	http://purl.uniprot.org/core/name	"Anticancer Res"xsd:string
http://purl.uniprot.org/citations/21508375	http://purl.uniprot.org/core/pages	"1271-1277"xsd:string
http://purl.uniprot.org/citations/21508375	http://purl.uniprot.org/core/title	"Claudin-4: a potential therapeutic target in chemotherapy-resistant ovarian cancer."xsd:string
http://purl.uniprot.org/citations/21508375	http://purl.uniprot.org/core/volume	"31"xsd:string
http://purl.uniprot.org/citations/21508375	http://www.w3.org/2004/02/skos/core#exactMatch	http://purl.uniprot.org/pubmed/21508375
http://purl.uniprot.org/citations/21508375	http://xmlns.com/foaf/0.1/primaryTopicOf	https://pubmed.ncbi.nlm.nih.gov/21508375
http://purl.uniprot.org/uniprot/#_B3KW38-mappedCitation-21508375	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/21508375
http://purl.uniprot.org/uniprot/#_B3KX18-mappedCitation-21508375	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/21508375
http://purl.uniprot.org/uniprot/#_Q75L80-mappedCitation-21508375	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/21508375
http://purl.uniprot.org/uniprot/#_O14493-mappedCitation-21508375	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/21508375
http://purl.uniprot.org/uniprot/B3KW38	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/21508375
http://purl.uniprot.org/uniprot/O14493	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/21508375
http://purl.uniprot.org/uniprot/Q75L80	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/21508375
http://purl.uniprot.org/uniprot/B3KX18	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/21508375