| http://purl.uniprot.org/citations/21509534 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21509534 | http://www.w3.org/2000/01/rdf-schema#comment | "The Drosophila melanogaster hematopoietic organ, called lymph gland, proliferates and differentiates throughout the larval period. The lymph gland of the late larva is comprised of a large primary lobe and several smaller secondary lobes. Differentiation into two types of hemocytes, plasmatocytes and crystal cells, is confined to the outer layer (cortical zone) of the primary lobe; the center of the primary lobe (medullary zone), as well as the secondary lobes, contain only proliferating prohemocytes. A small cluster of cells located at the posterior tip of the primary lobe serves as a signaling center (PSC) that inhibits precocious differentiation of the medullary zone. The larval lymph gland is stabilized by layers of extracellular matrix (basement membranes) that surround individual hemocytes, groups of hemocytes, as well as the lymph gland as a whole. In this paper, we investigated the events shaping the lymph gland in the early pupa. The lymph gland dissociates and hemocytes disperse during the first 12 h after puparium formation (APF), leaving behind empty husks of basement membrane. Prior to lymph gland dissociation, cells of the medullary zone differentiate, expressing the early differentiation marker Peroxidasin (Pxn), as well as, in part, the late differentiation marker P1. Cells of the PSC spread throughout the pupal lymph gland prior to their dispersal. Cells of the secondary lobes undergo a rapid phase of proliferation that lasts until 8 h APF, followed by expression of Pxn and dispersal. These hemocytes do not express P1, indicating that they disperse prior to full maturation."xsd:string |
| http://purl.uniprot.org/citations/21509534 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00427-011-0364-6"xsd:string |
| http://purl.uniprot.org/citations/21509534 | http://purl.uniprot.org/core/author | "Grigorian M."xsd:string |
| http://purl.uniprot.org/citations/21509534 | http://purl.uniprot.org/core/author | "Hartenstein V."xsd:string |
| http://purl.uniprot.org/citations/21509534 | http://purl.uniprot.org/core/author | "Mandal L."xsd:string |
| http://purl.uniprot.org/citations/21509534 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21509534 | http://purl.uniprot.org/core/name | "Dev Genes Evol"xsd:string |
| http://purl.uniprot.org/citations/21509534 | http://purl.uniprot.org/core/pages | "121-131"xsd:string |
| http://purl.uniprot.org/citations/21509534 | http://purl.uniprot.org/core/title | "Hematopoiesis at the onset of metamorphosis: terminal differentiation and dissociation of the Drosophila lymph gland."xsd:string |
| http://purl.uniprot.org/citations/21509534 | http://purl.uniprot.org/core/volume | "221"xsd:string |
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