| http://purl.uniprot.org/citations/21511814 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21511814 | http://www.w3.org/2000/01/rdf-schema#comment | "Genomic instability is related to a wide-range of human diseases. Here, we show that mitochondrial iron-sulfur cluster biosynthesis is important for the maintenance of nuclear genome stability in Saccharomyces cerevisiae. Cells lacking the mitochondrial chaperone Zim17 (Tim15/Hep1), a component of the iron-sulfur biosynthesis machinery, have limited respiration activity, mimic the metabolic response to iron starvation and suffer a dramatic increase in nuclear genome recombination. Increased oxidative damage or deficient DNA repair do not account for the observed genomic hyperrecombination. Impaired cell-cycle progression and genetic interactions of ZIM17 with components of the RFC-like complex involved in mitotic checkpoints indicate that replicative stress causes hyperrecombination in zim17Δ mutants. Furthermore, nuclear accumulation of pre-ribosomal particles in zim17Δ mutants reinforces the importance of iron-sulfur clusters in normal ribosome biosynthesis. We propose that compromised ribosome biosynthesis and cell-cycle progression are interconnected, together contributing to replicative stress and nuclear genome instability in zim17Δ mutants."xsd:string |
| http://purl.uniprot.org/citations/21511814 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/gkr193"xsd:string |
| http://purl.uniprot.org/citations/21511814 | http://purl.uniprot.org/core/author | "Herrero E."xsd:string |
| http://purl.uniprot.org/citations/21511814 | http://purl.uniprot.org/core/author | "Aguilera A."xsd:string |
| http://purl.uniprot.org/citations/21511814 | http://purl.uniprot.org/core/author | "Garcia-Rubio M.L."xsd:string |
| http://purl.uniprot.org/citations/21511814 | http://purl.uniprot.org/core/author | "Izquierdo A."xsd:string |
| http://purl.uniprot.org/citations/21511814 | http://purl.uniprot.org/core/author | "Gallardo M."xsd:string |
| http://purl.uniprot.org/citations/21511814 | http://purl.uniprot.org/core/author | "Wellinger R.E."xsd:string |
| http://purl.uniprot.org/citations/21511814 | http://purl.uniprot.org/core/author | "Diaz de la Loza M.d.e.l. C."xsd:string |
| http://purl.uniprot.org/citations/21511814 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21511814 | http://purl.uniprot.org/core/name | "Nucleic Acids Res"xsd:string |
| http://purl.uniprot.org/citations/21511814 | http://purl.uniprot.org/core/pages | "6002-6015"xsd:string |
| http://purl.uniprot.org/citations/21511814 | http://purl.uniprot.org/core/title | "Zim17/Tim15 links mitochondrial iron-sulfur cluster biosynthesis to nuclear genome stability."xsd:string |
| http://purl.uniprot.org/citations/21511814 | http://purl.uniprot.org/core/volume | "39"xsd:string |
| http://purl.uniprot.org/citations/21511814 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21511814 |
| http://purl.uniprot.org/citations/21511814 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21511814 |
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| http://purl.uniprot.org/uniprot/#_P42844-mappedCitation-21511814 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21511814 |
| http://purl.uniprot.org/uniprot/#_P32641-mappedCitation-21511814 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21511814 |
| http://purl.uniprot.org/uniprot/P32641 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21511814 |
| http://purl.uniprot.org/uniprot/P42844 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21511814 |
| http://purl.uniprot.org/uniprot/A0A6A5Q4R1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21511814 |