| http://purl.uniprot.org/citations/21514423 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21514423 | http://www.w3.org/2000/01/rdf-schema#comment | "Although the early growth response-2 (Egr-2, alias Krox20) protein shows structural and functional similarities to Egr-1, these two related early-immediate transcription factors are nonredundant. Egr-2 plays essential roles in peripheral nerve myelination, adipogenesis, and immune tolerance; however, its regulation and role in tissue repair and fibrosis remain poorly understood. We show herein that transforming growth factor (TGF)-β induced a Smad3-dependent sustained stimulation of Egr2 gene expression in normal fibroblasts. Overexpression of Egr-2 was sufficient to stimulate collagen gene expression and myofibroblast differentiation, whereas these profibrotic TGF-β responses were attenuated in Egr-2-depleted fibroblasts. Genomewide transcriptional profiling revealed that multiple genes associated with tissue remodeling and wound healing were up-regulated by Egr-2, but the Egr-2-regulated gene expression profile overlapped only partially with the Egr-1-regulated gene profile. Levels of Egr-2 were elevated in lesional tissue from mice with bleomycin-induced scleroderma. Moreover, elevated Egr-2 was noted in biopsy specimens of skin and lung from patients with systemic sclerosis. These results provide the first evidence that Egr-2 is a functionally distinct transcription factor that is both necessary and sufficient for TGF-β-induced profibrotic responses and is aberrantly expressed in lesional tissue in systemic sclerosis and in a murine model of scleroderma. Together, these findings suggest that Egr-2 plays an important nonredundant role in the pathogenesis of fibrosis. Targeting Egr-2 might represent a novel therapeutic strategy to control fibrosis."xsd:string |
| http://purl.uniprot.org/citations/21514423 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ajpath.2011.01.035"xsd:string |
| http://purl.uniprot.org/citations/21514423 | http://purl.uniprot.org/core/author | "Fang F."xsd:string |
| http://purl.uniprot.org/citations/21514423 | http://purl.uniprot.org/core/author | "Lin S."xsd:string |
| http://purl.uniprot.org/citations/21514423 | http://purl.uniprot.org/core/author | "Wu M."xsd:string |
| http://purl.uniprot.org/citations/21514423 | http://purl.uniprot.org/core/author | "Wei J."xsd:string |
| http://purl.uniprot.org/citations/21514423 | http://purl.uniprot.org/core/author | "Varga J."xsd:string |
| http://purl.uniprot.org/citations/21514423 | http://purl.uniprot.org/core/author | "Bhattacharyya S."xsd:string |
| http://purl.uniprot.org/citations/21514423 | http://purl.uniprot.org/core/author | "Du P."xsd:string |
| http://purl.uniprot.org/citations/21514423 | http://purl.uniprot.org/core/author | "Del Galdo F."xsd:string |
| http://purl.uniprot.org/citations/21514423 | http://purl.uniprot.org/core/author | "Feghali-Bostwick C.A."xsd:string |
| http://purl.uniprot.org/citations/21514423 | http://purl.uniprot.org/core/author | "Bhattachyya S."xsd:string |
| http://purl.uniprot.org/citations/21514423 | http://purl.uniprot.org/core/author | "Ooka K."xsd:string |
| http://purl.uniprot.org/citations/21514423 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21514423 | http://purl.uniprot.org/core/name | "Am J Pathol"xsd:string |
| http://purl.uniprot.org/citations/21514423 | http://purl.uniprot.org/core/pages | "2077-2090"xsd:string |
| http://purl.uniprot.org/citations/21514423 | http://purl.uniprot.org/core/title | "The early growth response gene Egr2 (Alias Krox20) is a novel transcriptional target of transforming growth factor-beta that is up-regulated in systemic sclerosis and mediates profibrotic responses."xsd:string |
| http://purl.uniprot.org/citations/21514423 | http://purl.uniprot.org/core/volume | "178"xsd:string |
| http://purl.uniprot.org/citations/21514423 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21514423 |
| http://purl.uniprot.org/citations/21514423 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21514423 |
| http://purl.uniprot.org/uniprot/#_A0A078BBI5-mappedCitation-21514423 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21514423 |
| http://purl.uniprot.org/uniprot/#_A0A078BC11-mappedCitation-21514423 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21514423 |
| http://purl.uniprot.org/uniprot/#_A0A078BCJ0-mappedCitation-21514423 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21514423 |
| http://purl.uniprot.org/uniprot/#_A0A078BCH8-mappedCitation-21514423 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21514423 |