| http://purl.uniprot.org/citations/21514639 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21514639 | http://www.w3.org/2000/01/rdf-schema#comment | "The speed of circadian clocks in animals is tightly linked to complex phosphorylation programs that drive daily cycles in the levels of PERIOD (PER) proteins. Using Drosophila, we identify a time-delay circuit based on hierarchical phosphorylation that controls the daily downswing in PER abundance. Phosphorylation by the NEMO/NLK kinase at the "per-short" domain on PER stimulates phosphorylation by DOUBLETIME (DBT/CK1δ/ɛ) at several nearby sites. This multisite phosphorylation operates in a spatially oriented and graded manner to delay progressive phosphorylation by DBT at other more distal sites on PER, including those required for recognition by the F box protein SLIMB/β-TrCP and proteasomal degradation. Highly phosphorylated PER has a more open structure, suggesting that progressive increases in global phosphorylation contribute to the timing mechanism by slowly increasing PER susceptibility to degradation. Our findings identify NEMO as a clock kinase and demonstrate that long-range interactions between functionally distinct phospho-clusters collaborate to set clock speed."xsd:string |
| http://purl.uniprot.org/citations/21514639 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2011.04.002"xsd:string |
| http://purl.uniprot.org/citations/21514639 | http://purl.uniprot.org/core/author | "Ko H.W."xsd:string |
| http://purl.uniprot.org/citations/21514639 | http://purl.uniprot.org/core/author | "Chiu J.C."xsd:string |
| http://purl.uniprot.org/citations/21514639 | http://purl.uniprot.org/core/author | "Edery I."xsd:string |
| http://purl.uniprot.org/citations/21514639 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21514639 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/21514639 | http://purl.uniprot.org/core/pages | "357-370"xsd:string |
| http://purl.uniprot.org/citations/21514639 | http://purl.uniprot.org/core/title | "NEMO/NLK phosphorylates PERIOD to initiate a time-delay phosphorylation circuit that sets circadian clock speed."xsd:string |
| http://purl.uniprot.org/citations/21514639 | http://purl.uniprot.org/core/volume | "145"xsd:string |
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| http://purl.uniprot.org/uniprot/#_A0A0B4KHX3-mappedCitation-21514639 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21514639 |
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| http://purl.uniprot.org/uniprot/#_Q2Q3V4-mappedCitation-21514639 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21514639 |
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| http://purl.uniprot.org/uniprot/#_Q2Q3V7-mappedCitation-21514639 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21514639 |