| http://purl.uniprot.org/citations/21518761 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21518761 | http://www.w3.org/2000/01/rdf-schema#comment | "The nature of inflammatory signals determines the outcome of T cell responses. However, little is known about how inflammatory cytokines provided to human CD8 T cells during activation affects their susceptibility to post-activation cell death. We have examined and compared the effects of the inflammatory cytokine IL-12, as well as the combination of IL-1, IL-6, and IL-23 (IL-1/6/23) on the susceptibility of primary human CD8 T cells to post-activation cell death. Human CD8 T cells activated in the presence of IL-1/6/23 underwent significantly less cell death after activation as compared with those activated in IL-12. This was due to reduced susceptibility to Fas-mediated activation-induced cell death (AICD). Mechanistically, the reduced level of cell death in CD8 T cells activated in IL-1/6/23 was a result of a low level of FasL expression and high level of c-FLIP(S) expression. When the effect of IL-1, IL-6, and IL-23 individually was examined, IL-1 or IL-6 alone was sufficient to inhibit CD8 T cell death that occurs after activation in IL-12. IL-1, but not IL-6, inhibited expression of FasL, whereas IL-6, but not IL-1, increased c-FLIP(S) expression. Our findings show that the presence of IL-1 and/or IL-6 during activation of human CD8 T cells attenuates Fas-mediated AICD, whereas IL-12 increases the susceptibility of activated CD8 T cells to this form of cell death."xsd:string |
| http://purl.uniprot.org/citations/21518761 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m110.197657"xsd:string |
| http://purl.uniprot.org/citations/21518761 | http://purl.uniprot.org/core/author | "Choy J.C."xsd:string |
| http://purl.uniprot.org/citations/21518761 | http://purl.uniprot.org/core/author | "Escalante N.K."xsd:string |
| http://purl.uniprot.org/citations/21518761 | http://purl.uniprot.org/core/author | "von Rossum A."xsd:string |
| http://purl.uniprot.org/citations/21518761 | http://purl.uniprot.org/core/author | "Krall R."xsd:string |
| http://purl.uniprot.org/citations/21518761 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21518761 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/21518761 | http://purl.uniprot.org/core/pages | "21137-21144"xsd:string |
| http://purl.uniprot.org/citations/21518761 | http://purl.uniprot.org/core/title | "Inflammatory cytokines determine the susceptibility of human CD8 T cells to Fas-mediated activation-induced cell death through modulation of FasL and c-FLIP(S) expression."xsd:string |
| http://purl.uniprot.org/citations/21518761 | http://purl.uniprot.org/core/volume | "286"xsd:string |
| http://purl.uniprot.org/citations/21518761 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21518761 |
| http://purl.uniprot.org/citations/21518761 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21518761 |
| http://purl.uniprot.org/uniprot/#_A0A1C9J7U0-mappedCitation-21518761 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21518761 |
| http://purl.uniprot.org/uniprot/#_B8ZZZ4-mappedCitation-21518761 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21518761 |
| http://purl.uniprot.org/uniprot/#_B4DVM1-mappedCitation-21518761 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21518761 |
| http://purl.uniprot.org/uniprot/#_B3KUU3-mappedCitation-21518761 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21518761 |
| http://purl.uniprot.org/uniprot/#_B4DNV3-mappedCitation-21518761 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21518761 |
| http://purl.uniprot.org/uniprot/#_B4DNQ5-mappedCitation-21518761 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21518761 |
| http://purl.uniprot.org/uniprot/#_B5MC21-mappedCitation-21518761 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21518761 |
| http://purl.uniprot.org/uniprot/#_H9C875-mappedCitation-21518761 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21518761 |
| http://purl.uniprot.org/uniprot/#_P01732-mappedCitation-21518761 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21518761 |
| http://purl.uniprot.org/uniprot/#_O60595-mappedCitation-21518761 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21518761 |
| http://purl.uniprot.org/uniprot/#_P01583-mappedCitation-21518761 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21518761 |