| http://purl.uniprot.org/citations/21518763 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21518763 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin-6 (IL-6) is a pleiotropic cytokine that plays a central role in host defense. IL-6 expression can be regulated at both a transcriptional and a post-transcriptional level. We used a combination of bioinformatics and experimental techniques to demonstrate that the miR-365 is a direct negative regulator of IL-6. Overexpression of miR-365 mimics decreased activity of a luciferase reporter containing the IL-6 3'-UTR and led to repression of IL-6 protein. In contrast, ectopic expression of a miR-365 inhibitor elevated IL-6 expression. The negative regulation of miR-365 was strictly dependent on a microRNA binding element in the 3'-UTR of IL-6 mRNA. Deletion mutant analysis of the miR-365 promoter showed that two transcription factors, Sp1 and NF-κB, are essential for the transcriptional regulation of miR-365. We also demonstrate that the MAPK/ERK pathway contributes to the regulation of miR-365. Furthermore, miR-365 exhibited a greater negative regulatory effect on IL-6 than hsa-let-7a, a previously identified microRNA negatively regulating IL-6. Taken together, our results show that miR-365 is a novel negative regulator of IL-6."xsd:string |
| http://purl.uniprot.org/citations/21518763 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m110.198630"xsd:string |
| http://purl.uniprot.org/citations/21518763 | http://purl.uniprot.org/core/author | "Wang D."xsd:string |
| http://purl.uniprot.org/citations/21518763 | http://purl.uniprot.org/core/author | "Zhong Y."xsd:string |
| http://purl.uniprot.org/citations/21518763 | http://purl.uniprot.org/core/author | "Xu Z."xsd:string |
| http://purl.uniprot.org/citations/21518763 | http://purl.uniprot.org/core/author | "Xu P."xsd:string |
| http://purl.uniprot.org/citations/21518763 | http://purl.uniprot.org/core/author | "Xie Q."xsd:string |
| http://purl.uniprot.org/citations/21518763 | http://purl.uniprot.org/core/author | "Chen H.C."xsd:string |
| http://purl.uniprot.org/citations/21518763 | http://purl.uniprot.org/core/author | "Cao L."xsd:string |
| http://purl.uniprot.org/citations/21518763 | http://purl.uniprot.org/core/author | "Luo R."xsd:string |
| http://purl.uniprot.org/citations/21518763 | http://purl.uniprot.org/core/author | "Xiao S.B."xsd:string |
| http://purl.uniprot.org/citations/21518763 | http://purl.uniprot.org/core/author | "Fang L.R."xsd:string |
| http://purl.uniprot.org/citations/21518763 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21518763 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/21518763 | http://purl.uniprot.org/core/pages | "21401-21412"xsd:string |
| http://purl.uniprot.org/citations/21518763 | http://purl.uniprot.org/core/title | "miR-365, a novel negative regulator of interleukin-6 gene expression, is cooperatively regulated by Sp1 and NF-kappaB."xsd:string |
| http://purl.uniprot.org/citations/21518763 | http://purl.uniprot.org/core/volume | "286"xsd:string |
| http://purl.uniprot.org/citations/21518763 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21518763 |
| http://purl.uniprot.org/citations/21518763 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21518763 |
| http://purl.uniprot.org/uniprot/#_A0A510GAH8-mappedCitation-21518763 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21518763 |
| http://purl.uniprot.org/uniprot/#_A0A1C9J7U0-mappedCitation-21518763 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21518763 |
| http://purl.uniprot.org/uniprot/#_C4PGM0-mappedCitation-21518763 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21518763 |
| http://purl.uniprot.org/uniprot/#_B4DVM1-mappedCitation-21518763 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21518763 |
| http://purl.uniprot.org/uniprot/#_B4DNV3-mappedCitation-21518763 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21518763 |