| http://purl.uniprot.org/citations/21518768 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21518768 | http://www.w3.org/2000/01/rdf-schema#comment | "Metalloprotease-disintegrin ADAM12 is overexpressed and frequently mutated in breast cancer. We report here that ADAM12 expression in cultured mammalian cells is up-regulated by Notch signals. Expression of a constitutively active form of Notch1 in murine fibroblasts, myoblasts, or mammary epithelial cells or activation of the endogenous Notch signaling by co-culture with ligand-expressing cells increases ADAM12 protein and mRNA levels. Up-regulation of ADAM12 expression by Notch requires new transcription, is activated in a CSL-dependent manner, and is abolished upon inhibition of IκB kinase. Expression of a constitutively active Notch1 in NIH3T3 cells increases the stability of Adam12 mRNA. We further show that the microRNA-29 family, which has a predicted conserved site in the 3'-untranslated region of mouse Adam12, plays a critical role in mediating the stimulatory effect of Notch on ADAM12 expression. In human cells, Notch up-regulates the expression of the long form, but not the short form, of ADAM12 containing a divergent 3'-untranslated mRNA region. These studies uncover a novel paradigm in Notch signaling and establish Adam12 as a Notch-related gene."xsd:string |
| http://purl.uniprot.org/citations/21518768 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m110.207951"xsd:string |
| http://purl.uniprot.org/citations/21518768 | http://purl.uniprot.org/core/author | "Li H."xsd:string |
| http://purl.uniprot.org/citations/21518768 | http://purl.uniprot.org/core/author | "Sun D."xsd:string |
| http://purl.uniprot.org/citations/21518768 | http://purl.uniprot.org/core/author | "Solomon E."xsd:string |
| http://purl.uniprot.org/citations/21518768 | http://purl.uniprot.org/core/author | "Zolkiewska A."xsd:string |
| http://purl.uniprot.org/citations/21518768 | http://purl.uniprot.org/core/author | "Duhachek Muggy S."xsd:string |
| http://purl.uniprot.org/citations/21518768 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21518768 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/21518768 | http://purl.uniprot.org/core/pages | "21500-21510"xsd:string |
| http://purl.uniprot.org/citations/21518768 | http://purl.uniprot.org/core/title | "Metalloprotease-disintegrin ADAM12 expression is regulated by Notch signaling via microRNA-29."xsd:string |
| http://purl.uniprot.org/citations/21518768 | http://purl.uniprot.org/core/volume | "286"xsd:string |
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