| http://purl.uniprot.org/citations/21518866 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21518866 | http://www.w3.org/2000/01/rdf-schema#comment | "Stem cell antigen (Sca)-1/Ly6A, a glycerophosphatidylinositol-linked surface protein, was found to be associated with murine stem cell- and progenitor cell-enriched populations, and also has been linked to the capacity of tumor-initiating cells. Despite these interesting associations, this protein's functional role in these processes remains largely unknown. To identify the mechanism underlying the protein's possible role in mammary tumorigenesis, Sca-1 expression was examined in Sca-1(+/EGFP) mice during carcinogenesis. Mammary tumor cells derived from these mice readily engrafted in syngeneic mice, and tumor growth was markedly inhibited on down-regulation of Sca-1 expression. The latter effect was associated with significantly elevated expression of the TGF-β ligand growth differentiation factor-10 (GDF10), which was found to selectively activate TGF-β receptor (TβRI/II)-dependent Smad3 phosphorylation. Overexpression of GDF10 attenuated tumor formation; conversely, silencing of GDF10 expression reversed these effects. Sca-1 attenuated GDF10-dependent TGF-β signaling by disrupting the heterodimerization of TβRI and TβRII receptors. These findings suggest a new functional role for Sca-1 in maintaining tumorigenicity, in part by acting as a potent suppressor of TGF-β signaling."xsd:string |
| http://purl.uniprot.org/citations/21518866 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1103441108"xsd:string |
| http://purl.uniprot.org/citations/21518866 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/21518866 | http://purl.uniprot.org/core/author | "Yin Y."xsd:string |
| http://purl.uniprot.org/citations/21518866 | http://purl.uniprot.org/core/author | "Yuan H."xsd:string |
| http://purl.uniprot.org/citations/21518866 | http://purl.uniprot.org/core/author | "Derynck R."xsd:string |
| http://purl.uniprot.org/citations/21518866 | http://purl.uniprot.org/core/author | "Upadhyay G."xsd:string |
| http://purl.uniprot.org/citations/21518866 | http://purl.uniprot.org/core/author | "Glazer R.I."xsd:string |
| http://purl.uniprot.org/citations/21518866 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21518866 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/21518866 | http://purl.uniprot.org/core/pages | "7820-7825"xsd:string |
| http://purl.uniprot.org/citations/21518866 | http://purl.uniprot.org/core/title | "Stem cell antigen-1 enhances tumorigenicity by disruption of growth differentiation factor-10 (GDF10)-dependent TGF-beta signaling."xsd:string |
| http://purl.uniprot.org/citations/21518866 | http://purl.uniprot.org/core/volume | "108"xsd:string |
| http://purl.uniprot.org/citations/21518866 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21518866 |
| http://purl.uniprot.org/citations/21518866 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21518866 |
| http://purl.uniprot.org/uniprot/#_A0A087WNT7-mappedCitation-21518866 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21518866 |
| http://purl.uniprot.org/uniprot/#_E9Q6I6-mappedCitation-21518866 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21518866 |
| http://purl.uniprot.org/uniprot/#_E9Q418-mappedCitation-21518866 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21518866 |
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| http://purl.uniprot.org/uniprot/#_Q62312-mappedCitation-21518866 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21518866 |
| http://purl.uniprot.org/uniprot/#_P97737-mappedCitation-21518866 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21518866 |
| http://purl.uniprot.org/uniprot/#_Q64729-mappedCitation-21518866 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21518866 |
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