http://purl.uniprot.org/citations/21520165 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/21520165 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundAbout 43% of men with low Gleason grade prostate cancer (PCa) at biopsy will be finally diagnosed with high-grade PCa at radical prostatectomy (RP). Gleason sum at RP is a good indicator of biochemical recurrence and poor clinical outcome. Therefore, there is a need to improve clinical evaluation of PCa aggressiveness in order to choice appropriate treatment. To this aim an easy-available tool is represented by circulating biomarkers. Among these, the best candidates are some molecules involved in PCa pathogenesis such as IGFBP-2 and IGFBP-3, IL-6, and its soluble receptor (SIL-6R).MethodsIn this study, we evaluated the ability of preoperative IGFBP-2, IGFBP-3, IL-6, and SIL-6R serum levels to predict Gleason score upgrade in 52 PCa patients.ResultsWe found that IGFBP-3 median levels were significantly lower in patients who showed Gleason upgrading from biopsy to RP (P = 0.024). We also found an association between biopsy T-stage and Gleason Upgrade (P = 0.011). Using multivariate logistic regression model, we demonstrated that the association of IGFBP-3 serum levels together with biopsy T-stage and biopsy Gleason score was useful to calculate a prognostic risk score. ROC curve analysis of risk score showed a good ability to predict GSU (AUC = 0.81; 95% CI 0.69-0.93).ConclusionsOur results suggest that preoperative IGFBP-3 circulating levels determination may be useful to predict Gleason score upgrading alone and/or in combination with biopsy T-stage and biopsy Gleason score."xsd:string |
http://purl.uniprot.org/citations/21520165 | http://purl.org/dc/terms/identifier | "doi:10.1002/pros.21411"xsd:string |
http://purl.uniprot.org/citations/21520165 | http://purl.uniprot.org/core/author | "Ferro M."xsd:string |
http://purl.uniprot.org/citations/21520165 | http://purl.uniprot.org/core/author | "Di Lorenzo G."xsd:string |
http://purl.uniprot.org/citations/21520165 | http://purl.uniprot.org/core/author | "Di Carlo A."xsd:string |
http://purl.uniprot.org/citations/21520165 | http://purl.uniprot.org/core/author | "Macchia V."xsd:string |
http://purl.uniprot.org/citations/21520165 | http://purl.uniprot.org/core/author | "Mariano A."xsd:string |
http://purl.uniprot.org/citations/21520165 | http://purl.uniprot.org/core/author | "Altieri V."xsd:string |
http://purl.uniprot.org/citations/21520165 | http://purl.uniprot.org/core/author | "Terracciano D."xsd:string |
http://purl.uniprot.org/citations/21520165 | http://purl.uniprot.org/core/author | "Bruzzese D."xsd:string |
http://purl.uniprot.org/citations/21520165 | http://purl.uniprot.org/core/author | "Mazzarella C."xsd:string |
http://purl.uniprot.org/citations/21520165 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
http://purl.uniprot.org/citations/21520165 | http://purl.uniprot.org/core/name | "Prostate"xsd:string |
http://purl.uniprot.org/citations/21520165 | http://purl.uniprot.org/core/pages | "100-107"xsd:string |
http://purl.uniprot.org/citations/21520165 | http://purl.uniprot.org/core/title | "Preoperative insulin-like growth factor-binding protein-3 (IGFBP-3) blood level predicts gleason sum upgrading."xsd:string |
http://purl.uniprot.org/citations/21520165 | http://purl.uniprot.org/core/volume | "72"xsd:string |
http://purl.uniprot.org/citations/21520165 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21520165 |
http://purl.uniprot.org/citations/21520165 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21520165 |
http://purl.uniprot.org/uniprot/#_B3KRZ1-mappedCitation-21520165 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21520165 |
http://purl.uniprot.org/uniprot/#_B3KRJ8-mappedCitation-21520165 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21520165 |
http://purl.uniprot.org/uniprot/#_B3KVF9-mappedCitation-21520165 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21520165 |
http://purl.uniprot.org/uniprot/#_A6XNC9-mappedCitation-21520165 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21520165 |
http://purl.uniprot.org/uniprot/#_A6XND0-mappedCitation-21520165 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21520165 |
http://purl.uniprot.org/uniprot/#_A6XND1-mappedCitation-21520165 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21520165 |