| http://purl.uniprot.org/citations/21521611 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21521611 | http://www.w3.org/2000/01/rdf-schema#comment | "Two families of Ca(2+)-binding proteins have been proposed as Ca(2+) sensors for spontaneous release: synaptotagmins and Doc2s, with the intriguing possibility that Doc2s may represent high-affinity Ca(2+) sensors that are activated by deletion of synaptotagmins, thereby accounting for the increased spontaneous release in synaptotagmin-deficient synapses. Here, we use an shRNA-dependent quadruple knockdown of all four Ca(2+)-binding proteins of the Doc2 family to confirm that Doc2-deficient synapses exhibit a marked decrease in the frequency of spontaneous release events. Knockdown of Doc2s in synaptotagmin-1-deficient synapses, however, failed to reduce either the increased spontaneous release or the decreased evoked release of these synapses, suggesting that Doc2s do not constitute Ca(2+) sensors for asynchronous release. Moreover, rescue experiments revealed that the decrease in spontaneous release induced by the Doc2 knockdown in wild-type synapses is fully reversed by mutant Doc2B lacking Ca(2+)-binding sites. Thus, our data suggest that Doc2s are modulators of spontaneous synaptic transmission that act by a Ca(2+)-independent mechanism."xsd:string |
| http://purl.uniprot.org/citations/21521611 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuron.2011.03.011"xsd:string |
| http://purl.uniprot.org/citations/21521611 | http://purl.uniprot.org/core/author | "Xu W."xsd:string |
| http://purl.uniprot.org/citations/21521611 | http://purl.uniprot.org/core/author | "Yang X."xsd:string |
| http://purl.uniprot.org/citations/21521611 | http://purl.uniprot.org/core/author | "Zhou P."xsd:string |
| http://purl.uniprot.org/citations/21521611 | http://purl.uniprot.org/core/author | "Sudhof T.C."xsd:string |
| http://purl.uniprot.org/citations/21521611 | http://purl.uniprot.org/core/author | "Pang Z.P."xsd:string |
| http://purl.uniprot.org/citations/21521611 | http://purl.uniprot.org/core/author | "Bacaj T."xsd:string |
| http://purl.uniprot.org/citations/21521611 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21521611 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
| http://purl.uniprot.org/citations/21521611 | http://purl.uniprot.org/core/pages | "244-251"xsd:string |
| http://purl.uniprot.org/citations/21521611 | http://purl.uniprot.org/core/title | "Doc2 supports spontaneous synaptic transmission by a Ca(2+)-independent mechanism."xsd:string |
| http://purl.uniprot.org/citations/21521611 | http://purl.uniprot.org/core/volume | "70"xsd:string |
| http://purl.uniprot.org/citations/21521611 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21521611 |
| http://purl.uniprot.org/citations/21521611 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21521611 |
| http://purl.uniprot.org/uniprot/Q9ESN1#attribution-4BA0BE654935000E5C1908241B1CACA0 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21521611 |
| http://purl.uniprot.org/uniprot/Q7TNF0#attribution-773A70D0493498FCDA88B074A2466CF1 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21521611 |
| http://purl.uniprot.org/uniprot/P70169#attribution-773A70D0493498FCDA88B074A2466CF1 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21521611 |
| http://purl.uniprot.org/uniprot/P47708#attribution-4BA0BE654935000E5C1908241B1CACA0 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21521611 |
| http://purl.uniprot.org/uniprot/P46096#attribution-1D1DB0BDD46C81607F25A6F20390BCBA | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21521611 |
| http://purl.uniprot.org/uniprot/P46096#attribution-773A70D0493498FCDA88B074A2466CF1 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21521611 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YV12-mappedCitation-21521611 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21521611 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RNM8-mappedCitation-21521611 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21521611 |
| http://purl.uniprot.org/uniprot/#_D3YYV2-mappedCitation-21521611 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21521611 |